Search for dissertations about: "statistics nonparametric"

Showing result 1 - 5 of 42 swedish dissertations containing the words statistics nonparametric.

  2. 1. Development and Evaluation of Nonparametric Mixed Effects Models

    Author : Paul Baverel; Mats Karlsson; Radojka Savic; Nils Hoem; Uppsala universitet; []
    Keywords : NATURVETENSKAP; NATURAL SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; nonparametric; model; pharmacometrics; pharmacokinetics; pharmacodynamic; imprecision; covariate analysis; parameter distribution; Statistics; computer and systems science; Statistik; data- och systemvetenskap; Pharmaceutical pharmacology; Farmaceutisk farmakologi; Biopharmaceutics; Biofarmaci; Clinical Pharmacology; Klinisk farmakologi; Computer Systems; Datorteknik; Farmakologi; Pharmacology; Statistics; Statistik;

    Abstract : A nonparametric population approach is now accessible to a more comprehensive network of modelers given its recent implementation into the popular NONMEM application, previously limited in scope by standard parametric approaches for the analysis of pharmacokinetic and pharmacodynamic data. The aim of this thesis was to assess the relative merits and downsides of nonparametric models in a nonlinear mixed effects framework in comparison with a set of parametric models developed in NONMEM based on real datasets and when applied to simple experimental settings, and to develop new diagnostic tools adapted to nonparametric models. READ MORE

  4. 2. Nonparametric tests for comparing two treatments by using ordinal data

    Author : Helen Wahlström; Elisabeth Svensson; Jan Lanke; Sture Holm; Örebro universitet; []
    Keywords : NATURVETENSKAP; NATURAL SCIENCES; Statistik; change; clinical trial; Monte Carlo; ordered categorical data; paired data; permutation test; Pitman efficiency; power; stratification; ties; visual analogue scale; Wilcoxon-Mann-Whitney statistic; statistik; Statistics; Statistik; Statistics; Statistik;

    Abstract : This thesis concerns four nonparametric tests for comparing two treatments in a randomized controlled clinical trial when the main response variable generates discrete or continuous ordinal data and measurements are made at baseline and follow-up. In the Wilcoxon-Mann-Whitney test (WMW) the baseline values are not taken into account at all, but in the other three tests both baseline and follow-up values are used. READ MORE

  5. 3. Nonparametric Statistical Inference for Entropy-type Functionals

    Author : David Källberg; Oleg Seleznjev; Timo Koski; Umeå universitet; []
    Keywords : NATURVETENSKAP; NATURAL SCIENCES; entropy estimation; Rényi entropy; divergence estimation; quadratic density functional; U-statistics; consistency; asymptotic normality; Poisson convergence; stationary m-dependent sequence; inter-point distances; entropy maximizing distribution; two-sample problem; approximate matching; Mathematical Statistics; matematisk statistik;

    Abstract : In this thesis, we study statistical inference for entropy, divergence, and related functionals of one or two probability distributions. Asymptotic properties of particular nonparametric estimators of such functionals are investigated. We consider estimation from both independent and dependent observations. READ MORE

  6. 4. Pointwise and Genomewide Significance Calculations in Gene Mapping through Nonparametric Linkage Analysis: Theory, Algorithms and Applications

    Author : Lars Ängquist; Matematisk statistik; []
    Keywords : NATURVETENSKAP; NATURAL SCIENCES; programming; actuarial mathematics; Statistik; cytogenetics; Genetik; cytogenetik; Mathematics; Matematik; Statistics; operations research; Genetics; ROC curves; conditioning loci; optimal score functions; noncentrality parameter; cost adjusted relative efficiency; exponential tilting; importance sampling; Monte Carlo simulation; normal approximation; crossover rate; process maximum; analytical approximation; significance calculations; NPL score; conditional linkage analysis; two-locus linkage analysis; Allele sharing; aktuariematematik; operationsanalys; programmering; gene-gene interaction; composite hypotheses; genetic disease models; classes of score functions; nonparametric linkage analysis;

    Abstract : In linkage analysis or, in a wider sense, gene mapping one searches for disease loci along a genome. This is done by observing so called marker genotypes (alleles) and phenotypes (affecteds/unaffecteds) of a pedigree set, i.e. READ MORE

  7. 5. Selection of smoothing parameters with application in causal inference

    Author : Jenny Häggström; Xavier de Luna; Marie Wiberg; Yanyuan Ma; Umeå universitet; []
    Keywords : NATURVETENSKAP; NATURAL SCIENCES; Smoothing parameter selection; Nonparametric regression; Semiparametric additive model; Double smoothing; Causal inference; BMI; Divorce; Statistics; Statistik; Statistics; statistik;

    Abstract : This thesis is a contribution to the research area concerned with selection of smoothing parameters in the framework of nonparametric and semiparametric regression. Selection of smoothing parameters is one of the most important issues in this framework and the choice can heavily influence subsequent results. READ MORE