Search for dissertations about: "stem cell differentiation"

Showing result 1 - 5 of 441 swedish dissertations containing the words stem cell differentiation.

  2. 1. Pancreatic extracellular communication. Applications to beta cell cultures and islet amyloid polypeptide aggregation

    Author : Diana Ribeiro; Chalmers tekniska högskola; []
    Keywords : NATURVETENSKAP; NATURAL SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; in vitro pancreatic models; induced pluripotent stem cells; stem cell differentiation; insulin; 3D-culture; extracellular vesicles; glucose-stimulated insulin secretion; islet amyloid polypeptide; type 2 diabetes mellitus; extracellular matrix; adipose-derived stem cells; Diabetes mellitus; protein aggregation;

    Abstract : Diabetes mellitus (DM) is a disease with epidemic proportions due to increased incidences worldwide, persistence of undiagnosed cases, uncontrolled forms of the disease, association with cardiovascular complications, and lack of definitive treatment options. In particular, type 2 DM (T2DM) is placing an enormous financial burden on worldwide healthcare systems that will increase in the futureThere is a need to develop physiological assay platforms that provide functionally relevant models of diabetes in order to accelerate the discovery of new treatments. READ MORE

  4. 2. Creating cell microenvironments in vitro

    Author : Patric Wallin; Chalmers tekniska högskola; []
    Keywords : NATURVETENSKAP; NATURAL SCIENCES; NATURVETENSKAP; NATURAL SCIENCES; TEKNIK OCH TEKNOLOGIER; ENGINEERING AND TECHNOLOGY; NATURVETENSKAP; NATURAL SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; cell migration; lipid bilayers; cell differentiation; liquid handling; surface functionalization; Microfluidics; chemotractant gradients; mammalian cell culture; cell microenvironments; in vitro screening assay;

    Abstract : Stem cells have a great potential to bring about advancements in fields like developmental biology, drug discovery, cancer biology and tissue engineering. In order to be able to use stem cells to their full potential, it is important to have control over their behavior. READ MORE

  5. 3. Identification of Unique Hematopoietic Stem Cell Properties

    Author : Jens Nygren; Lunds universitet; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Kardiovaskulära systemet; Cardiovascular system; Hematologi; extracellulära vätskor; Haematology; extracellular fluids; cell cycle; fusion; transdifferentiation; plasticity; Medicine human and vertebrates ; Medicin människa och djur ; quiescence; hematopoietic stem cell; self-renewal;

    Abstract : Hematopoietic stem cells (HSC) are sufficient and required for life long production of all blood cell lineages. Steady state HSCs are largely quiescent and we demonstrate that the kinetics of HSC cell cycling are slower compared to more committed progenitor cells also during expansion and self-renewal ex vivo and in physiological conditions. READ MORE

  6. 4. Neural Stem Cell Differentiation and Migration

    Author : Anna Erlandsson; Karin Forsberg-Nilsson; Bengt Westermark; Christer Betsholtz; Uppsala universitet; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Medicine; CNS; stem cells; neuron; PDGF; SCF; differentiation; migration; ERK; Medicin; Dermatology and venerology; clinical genetics; internal medicine; Dermatologi och venerologi; klinisk genetik; invärtesmedicin; Medicinsk biokemi; Medical Biochemistry;

    Abstract : Neural stem cells are the precursors of neurons, astrocytes and oligodendrocytes. During neural development, the division of stem cells takes place close to the lumen of the neural tube, after which they migrate to their final positions within the central nervous system (CNS). READ MORE

  7. 5. Novel Regulators of Brain Tumor Development : – From neural stem cell differentiation to in vivo models

    Author : Anqi Xiong; Karin Forsberg Nilsson; Joanna Phillips; Uppsala universitet; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; glioma; medulloblastoma; neural stem cell; heparanase; NRBP2; dog models; susceptibility;

    Abstract : Malignant brain tumors are diseases with poor prognosis and/or severe long-term side effects of treatment. This thesis aimed to discover novel regulators in brain tumor development, based on studying neural stem cell and progenitor cell (NSPC) differentiation and using animal models to introduce new insights to mechanisms of human brain tumors. READ MORE