Search for dissertations about: "stem"

Showing result 6 - 10 of 1499 swedish dissertations containing the word stem.

2. 6. Towards Generation of Human Hematopoietic Stem Cells from Pluripotent Stem Cells

   Author : Roger Rönn; Avdelningen för molekylärmedicin och genterapi; []
   Keywords : NATURVETENSKAP; NATURAL SCIENCES; Hematopoietic stem cells; pluripotent stem cells; embryonic development.; in vitro differentiation;

   Abstract : There is a pressing need for compatible Hematopoietic Stem Cells (HSCs), in high quantities and of good clinical quality, to ensure optimal treatment for patients with various blood malignancies. Pluripotent Stem Cells (PSCs) have the potential to be a source for generating HSCs. READ MORE

4. 7. High temperature corrosion of some selected stainless steels and Ni-base alloys – an advanced microscopy study

   Author : Nooshin Mortazavi Seyedeh; Chalmers tekniska högskola; []
   Keywords : TEKNIK OCH TEKNOLOGIER; ENGINEERING AND TECHNOLOGY; NATURVETENSKAP; NATURAL SCIENCES; TEKNIK OCH TEKNOLOGIER; ENGINEERING AND TECHNOLOGY; oxidation; KCl; STEM; high-temperature materials; STEM EDX; TKD.;

   Abstract : The thesis deals with high temperature corrosion behavior of some selective stainless steels and Ni-base alloys with applications in power generation technologies, e.g. boilers fired by biomass and waste. READ MORE

5. 8. Novel Insights into Haematopoietic Stem Cell Regulation and Function

   Author : Sarah Warsi; Avdelningen för molekylärmedicin och genterapi; []
   Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Haematopoiesis; Haematopoietic stem cell; Stem cell regulation; Haematopoietic stem cell transplantation;

   Abstract : The haematopoietic stem cell (HSC) is a somatic stem cell essential for life long haematopoiesis; HSCs have the capability to differentiate into all mature types of blood cells and can also undergo self-renewal to maintain their own numbers. They also have the potential to reconstitute a complete haematopoietic system following HSC transplantation, also known as bone marrow transplantation, which is used to treat many haematopoietic disorders. READ MORE

6. 9. Potential Hazards for Haematopoietic Stem Cell Donors

   Author : Simon Pahnke; Hans Hägglund; Gunnar Larfors; Nina Worel; Uppsala universitet; []
   Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; stem cell donor; stem cell transplantation; cancer; haematology; Medicinsk vetenskap; Medical Science;

   Abstract : The aim of this thesis has been to increase our knowledge about the allogeneic stem cell donation procedure and the associated risks for stem cell donors.  In a first study (paper I), we described the donation procedure and short-term side effects of 1957 donors included in the Nordic Register of Haematopoietic Stem Cell Donors. READ MORE

7. 10. Development of Gene Therapy for Hematopoietic Stem Cells using Lentiviral Vectors

   Author : Niels-Bjarne Woods; Andreas Ooka; Stefan Karlsson; Avdelningen för molekylärmedicin och genterapi; []
   Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; embryonic stem cell; Hematopoietic stem cell; lentiviral vector; transduction efficiency; transgene expression; multiple vector copy integration; insertional mutagenesis; NOD SCID mouse; cytogenetics; Genetics; extracellulära vätskor; extracellular fluids; cytogenetik; Genetik; Haematology; Hematologi; Lentivirus : genetics; Human; Genetic Vectors; Hematopoietic Stem Cells : metabolism; Animal; Gene Therapy; Leukemia : therapy; Leukemia : metabolism;

   Abstract : Hematopoietic stem cells are an ideal target for genetic manipulation for the purpose of curing hematological disorders as they have the ability to develop into all blood lineages and to self-renew. In this study we demonstrate that lentiviral vectors, based on HIV-1, can efficiently transfer genes into human hematopoietic progenitor and stem cells as assessed following stem cell transplantation in immune compromised mice. READ MORE