Search for dissertations about: "steroid receptor"

Showing result 1 - 5 of 149 swedish dissertations containing the words steroid receptor.

  1. 1. GABA-steroid effects in healthy subjects and women with polycystic ovary syndrome

    Author : Helena Hedström; Torbjörn Bäckström; Marie Bixo; Ian Milsom; Umeå universitet; []
    Keywords : MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Allopregnanolone; isoallopregnanolone; gonadotropins; GABA-A receptor; women; polycystic ovary syndrome; saccade; obstetrik och gynekologi; Obstetrics and Gynaecology;

    Abstract : Background: The progesterone metabolite allopregnanolone is involved in several clinical conditions in women, e.g. premenstrual dysphoric disorder. It is a very potent GABA-steroid with GABA-A receptor effects similar to other GABA-agonists, e. READ MORE

  2. 2. Steroid-Metabolizing Cytochrome P450 (CYP) Enzymes in the Maintenance of Cholesterol and Sex Hormone Levels

    Author : Hanna Pettersson; Maria Norlin; Kjell Wikvall; Paolo Parini; Uppsala universitet; []
    Keywords : MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; CYP27A1; CYP7B1; cytochrome P450; estrogen receptor; androgen receptor; cholesterol; sex hormone; hydroxylation; steroid metabolism; regulation of steroid levels; Pharmaceutical biochemistry; Farmaceutisk biokemi; Farmaceutisk biokemi; Pharmaceutical Biochemistry;

    Abstract : The enzymes CYP27A1 and CYP7B1 are widely expressed in various human tissues and perform catalytic reactions in cholesterol homeostasis and endocrine signaling. We have investigated the metabolism of a synthetic oxysterol. READ MORE

  3. 3. Combinatorial Methodology. Screening for affinity specific ligands to biological and artificial receptors

    Author : Margareta Krook; Tillämpad biokemi; []
    Keywords : NATURVETENSKAP; NATURAL SCIENCES; NATURVETENSKAP; NATURAL SCIENCES; peptide library; combinatorial; screening; phage display; affinity; DNA-interaction; chymotrypsin; peptide inhibitor; antibody; IgG; Fc; molecular imprinting; steroid; receptor; Biochemistry; Metabolism; Biokemi; Biotechnology; Bioteknik;

    Abstract : Combinatorial screening methodology has been employed to select new affinity specific ligands to bilogical and artificial receptors. The screening methodology, in particular screening of combinatorial phage display peptide libraries against target molecules differing in function and shape, is focused upon. READ MORE

  4. 4. Polymorphism in sex steroid-related genes. Effects on hormone levels and behavior

    Author : Lars Westberg; Göteborgs universitet; Göteborgs universitet; Gothenburg University; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; MEDICAL AND HEALTH SCIENCES; sex steroids; androgen receptor; estrogen receptor; progesterone receptor; polymorphism; genetics; association study; prolactin; personality; premenstrual dysphoric disorder; Parkinson s disease;

    Abstract : Genetic factors are important for variations between individuals with respect to most humantraits and diseases. Sex steroids are of profound importance for reproduction, metabolism,cardiovascular function and bone formation. They are potent regulators of their ownsynthesis as well as of that of other hormones, including prolactin. READ MORE

  5. 5. On the influence of serotonin- and sex steroid-related genetic variation on mood, anxiety, personality, autism and transsexualism

    Author : Susanne Henningsson; Göteborgs universitet; Göteborgs universitet; Gothenburg University; []
    Keywords : serotonin; 5-HTTLPR; TPH2; 5-HT3; sex steroids; androgen receptor; estrogen receptor; genetics; gene-gene interaction; social phobia; anxiety; premenstrual dysphoric disorder; depression; personality; autism; transsexualism; amygdala; emotional perception; life events;

    Abstract : Background: The neurotransmitter serotonin has been related to mood and anxiety, and variation in genes that encode important members of the serotonergic system may hence affect mood- and anxiety-related traits. Sex steroids influence brain development, and variation in genes encoding androgen and estrogen receptors, or enzymes needed for sex steroid synthesis, may be of importance for both personality traits and risk for psychiatric disorders. READ MORE