Search for dissertations about: "stn"
Showing result 1 - 5 of 19 swedish dissertations containing the word stn.
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1. Across Borders : A Histological and Physiological Study of the Subthalamic Nucleus in Reward and Movement
Abstract : The basal ganglia are the key circuitry controlling movement and reward behavior. Both locomotion and reward-related behavior are also modified by dopaminergic input from the substantia nigra and the ventral tegmental area (VTA). READ MORE
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2. The subthalamic nucleus in motor and affective functions : An optogenetic in vivo-investigation
Abstract : The basal ganglia form a group of subcortical interconnected nuclei involved in motor, limbic and cognitive functions. According to the classical model of the basal ganglia, two main pathways exert opposing control over movement, one facilitating movement and the other suppressing movement. READ MORE
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3. Characterisation of inputs and outputs of striatal medium spiny neurons in health and disease
Abstract : Striatal medium spiny neurons (MSNs) play a crucial role in various motor and cognitive functions. They are separated into those belonging to the direct pathway (dMSNs) and the indirect pathway (iMSNs) of the basal ganglia, depending on whether they express D1 or D2 type dopamine receptors, respectively. READ MORE
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4. Balance performance in people with Parkinson’s disease. Effects of subthalamic Deep Brain Stimulation
Abstract : The overall aims of this work were to investigate if Deep Brain Stimulation in the subthalamic nuclei (STN) affected balance, fear of falling and falls in people with Parkinson's disease. The effect of STN stimulation alone was investigated in Papers I, II and III. READ MORE
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5. Utility of novel drug targets for treatment of metastatic cancer
Abstract : Metastasis is the leading cause of cancer death because of a lack of early diagnosis tools and efficient treatment drugs. The lipid kinase phosphatidylinositol 4-phosphate 5 kinase (PIP5K1α) has been shown to play a vital role in the PI3K/AKT and KRAS signaling pathways. READ MORE