Search for dissertations about: "streptozotocin mouse"
Showing result 1 - 5 of 13 swedish dissertations containing the words streptozotocin mouse.
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1. Experimental diabetes mellitus in the mouse : a study of the action of streptozotocin on the pancreatic B-cell
Abstract : .... READ MORE
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2. Investigations of Strategies to Counteract Proinflammatory Cytokines in Experimental Type 1 Diabetes
Abstract : Type 1 diabetes (T1D) is a chronic autoimmune disease targeted against the pancreatic β-cells. Proinflammatory cytokines are considered to play a major role in the destruction of the insulin-producing β-cells. This thesis studied strategies to counteract proinflammatory cytokines in experimental T1D. READ MORE
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3. The Tyrosine Kinase GTK : Signal Transduction and Biological Function
Abstract : Protein tyrosine kinases play an important role in the regulation of various cellular processes such asgrowth, differentiation and survival. GTK, a novel SRC-like cytoplasmic tyrosine kinase, was recently cloned from a mouse insulinoma cell line and the present work was conducted in order to find a biological function of GTK in insulin producing and neuronal cells. READ MORE
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4. Anti-Diabetic and Beta-Cell Protective Actions of Imatinib Mesylate
Abstract : Type 1 diabetes is a disease resulting from the progressive immune-mediated destruction of insulin producing β-cells. In order to understand more about diabetes we need to understand the mechanisms governing β-cell death.The leukemia drug Gleevec is a tyrosine kinase inhibitor that targets c-Abl. READ MORE
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5. The role of CART in islet function
Abstract : Diminished insulin secretion and dysregulated glucagon secretion are key features of type 2 diabetes (T2D). The overall aim of this thesis was to study the role of cocaine- and amphetamine-regulated transcript (CART) in islet cell function and how CART regulates glucose homeostasis. READ MORE