Search for dissertations about: "streptozotocin"

Showing result 1 - 5 of 39 swedish dissertations containing the word streptozotocin.

  1. 1. The Tyrosine Kinase GTK Signal Transduction and Biological Function

    University dissertation from Uppsala : Acta Universitatis Upsaliensis

    Author : Cecilia Annerén; [2001]
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Cell biology; Protein tyrosine kinases; GTK; SHB; proliferation; survival; differentiation; β cells; pancreatectomy; cytokines; diabetes; PC12 cells; NGF; streptozotocin; focal adhesion kinase; RAP1; Cellbiologi; MEDICINE Morphology; cell biology; pathology Cell biology; MEDICIN Morfologi; cellbiologi; patologi Cellbiologi; medicinsk cellbiologi; Medical Cell Biology;

    Abstract : Protein tyrosine kinases play an important role in the regulation of various cellular processes such asgrowth, differentiation and survival. GTK, a novel SRC-like cytoplasmic tyrosine kinase, was recently cloned from a mouse insulinoma cell line and the present work was conducted in order to find a biological function of GTK in insulin producing and neuronal cells. READ MORE

  2. 2. Investigations of Strategies to Counteract Proinflammatory Cytokines in Experimental Type 1 Diabetes

    University dissertation from Uppsala : Acta Universitatis Upsaliensis

    Author : Andreas Börjesson; Stellan Sandler; Annika Carlsson; Jens Nielsen; [2008]
    Keywords : LANTBRUKSVETENSKAPER; AGRICULTURAL SCIENCES; Type 1 diabetes; proinflammatory cytokines; SOCS-3; pancreatic islets; inducible nitric oxide synthase; insulin secretion; NOD mice; islet transplantation; proinsulin conversion; streptozotocin; prolactin; VETERINARY MEDICINE Medicine; VETERINÄRMEDICIN Medicin;

    Abstract : Type 1 diabetes (T1D) is a chronic autoimmune disease targeted against the pancreatic β-cells. Proinflammatory cytokines are considered to play a major role in the destruction of the insulin-producing β-cells. This thesis studied strategies to counteract proinflammatory cytokines in experimental T1D. READ MORE

  3. 3. MEKK-1 and NF-κB Signaling in Pancreatic Islet Cell Death

    University dissertation from Uppsala : Acta Universitatis Upsaliensis

    Author : Dariush Mokhtari; Nils Welsh; Michael Welsh; Anders Tengholm; Shanta Persaud; [2008]
    Keywords : Cell biology; MEKK-1; JNK; human islets; β-cells; siRNA; apoptosis; cell death; MAPK; nitric oxide; cytokines; streptozotocin; c-Rel; NF-κB; Cellbiologi;

    Abstract : Type 1 diabetes is an autoimmune disease resulting in the selective destruction of the insulin producing β-cells in the pancreas. Pro-inflammatory cytokines and the free radical nitric oxide (NO) have been implicated in mediating the destruction of β-cells, possibly through activation of the mitogen activated protein kinases (MAPKs) JNK, ERK and p38. READ MORE

  4. 4. Experimental Studies Aiming to Prevent Type 1 Diabetes Mellitus

    University dissertation from Uppsala : Acta Universitatis Upsaliensis

    Author : Tobias Rydgren; Uppsala universitet.; [2007]
    Keywords : Cell biology; Diabetes; Interleukin-1 trap; Simvastatin; Nitric oxide synthase; Cytokine; Pancreatic islet; Streptozotocin; Transplantation; Cellbiologi;

    Abstract : Type 1 diabetes mellitus (T1DM) is an autoimmune disease in which T-cells and macrophages invade the islets of Langerhans and selectively destroy the insulin producing β-cells, either directly or through the secretion of e.g. cytokines and nitric oxide (NO). This thesis has studied possible strategies to prevent T1DM. READ MORE

  5. 5. Role of Inducible Nitric Oxide Synthase and Melatonin in Regulation of β-cell Sensitivity to Cytokines

    University dissertation from Uppsala : Acta Universitatis Upsaliensis

    Author : Annika K. Andersson; Stellan Sandler; Nils Welsh; Décio L. Eizirik; Nils Billestrup; [2003]
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Cell biology; β-cell; Cyclooxygenase; Cytokine; Diabetes; IFN-γ; IL-1β; iNOS; Insulin; Melatonin; Nitric oxide; Pancreatic islets; Phospholipase D; Prostaglandin E2; Streptozotocin; Cellbiologi; MEDICINE Morphology; cell biology; pathology Cell biology; MEDICIN Morfologi; cellbiologi; patologi Cellbiologi;

    Abstract : The mechanisms of β-cell destruction leading to type 1 diabetes are complex and not yet fully understood, but infiltration of the islets of Langerhans by autoreactive immune cells is believed to be important. Activated macrophages and T-cells may then secrete cytokines and free radicals, which could selectively damage the β-cells. READ MORE