Search for dissertations about: "streptozotocin"

Showing result 21 - 25 of 40 swedish dissertations containing the word streptozotocin.

  2. 21. Exploration of Conditions Affecting Cytokine Production in Experimental Type 1 Diabetes Mellitus

    Author : Lina Thorvaldson; Stellan Sandler; Michael Welsh; Maria Holstad; Maria Faresjö; Uppsala universitet; []
    Keywords : Cell biology; Cytokine; Diabetes; Tumor necrosis factor-α; Interferon-γ; Interleukin-4; Interleukin-10; Transplantation; Pancreatic islet; Glucose; Regulatory T cell; Cellbiologi;

    Abstract : Cytokines are soluble signalling mediators within the immune system, and have been shown to be of importance in the development of type 1 diabetes (T1D). This thesis studied the production of cytokines in experimental models of T1D and during transplantation of insulin-producing islets of Langerhans. READ MORE

  4. 22. Gene therapy in a new model of delayed wound healing

    Author : Patrik Velander; Kirurgi; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; IGF-1; Gene therapy; Diabetes; Animal model; EGF;

    Abstract : Diabetes wounds result in significant morbidity, prolonged hospitalization and huge health care expenses. As of yet, no optimal animal models of diabetic wound healing exist to study potential beneficial therapies. Porcine wound healing is very similar to human wound healing. READ MORE

  5. 23. Prevention of type 1 diabetes mellitus in experimental studies

    Author : Maria Holstad; Uppsala universitet; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Cell biology; Cytokines; inducible nitric oxide synthase; nitric oxide; NOD mice; pancreatic islets; prolactin; syngeneic islet transplantation; tumour necrosis factor alpha; type 1 diabetes mellitus; Cellbiologi; Cell biology; Cellbiologi; medicinsk cellbiologi; Medical Cell Biology;

    Abstract : The aim of the study was to examine the immune response and different immunoprotective strategies in experimental type 1 diabetes mellitus. The autoimmune destruction of the insulin-producing pancreatic β-cells that leads to type 1 diabetes is complex and incompletely understood. READ MORE

  6. 24. Autoimmune Regulator Deficient Mice, an Animal Model of Autoimmune Polyendocrine Syndrome Type I

    Author : Signe Hässler; Ola Winqvist; Olle Kämpe; Bertrand Huard; Uppsala universitet; []
    Keywords : Molecular medicine; autoimmune regulator; autoimmune polyendocrine syndrome type I; peripheral tolerance; antigen presenting cells; autoimmunity; danger signal; knockout mice; Molekylärmedicin;

    Abstract : Autoimmune diseases develop when the immune system fails to distinguish self from non-self or when the immune system is hypersensitive to endogenous or exogenous danger signals, or when a tissue erroneously sends a danger signal to the immune system. The education of the immune system to distinguish self from non-self is mainly carried out in the thymus and gives rise to central tolerance, whereas the ability to sense a danger or a healthy tissue constitutes peripheral tolerance. READ MORE

  7. 25. Growth factors and their interaction in the regulation of vascular cells : with special reference to diabetes

    Author : Gunilla Dahlfors; Linköpings universitet; []
    Keywords : MEDICINE; MEDICIN;

    Abstract : Proliferation of vascular smooth muscle cells plays an important role in the development of atherosclerosis and in restenosis following balloon angioplasty. This study focuses on growth factors associated with diabetic vascular disease and their interaction in the regulation of vascular smooth muscle cell growth. READ MORE