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Showing result 1 - 5 of 30 swedish dissertations matching the above criteria.
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1. Phenotypic Specification of Striatal Progenitors; Evidence for both cell-autonomous and environmental control as studied by transplantation into the adult and developing rodent brain
Abstract : The striatum is the major component of the ventral telencephalon and basal ganglia, involved in the processing of cortical information. The vast majority of the neuronal population in the striatum are striatal projection neurons, with connection to the globus pallidus and substantia nigra. READ MORE
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2. Modeling receptor induced signaling in MSNs : Interaction between molecules involved in striatal synaptic plasticity
Abstract : Basal Ganglia are evolutionarily conserved brain nuclei involved in several physiologically important animal behaviors like motor control and reward learning. Striatum, which is the input nuclei of basal ganglia, integrates inputs from several neurons, like cortical and thalamic glutamatergic input and local GABAergic inputs. READ MORE
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3. Striatal adenosine A2A receptors
Abstract : The nucleoside adenosine exerts a modulatory action in the central nervous system by activating G-protein coupled receptors. Four such receptors are cloned and pharmacologically characterized: A1, A2A, A2B and A3. Caffeine, the most widely consumed psychostimulant, acts as an adenosine receptor antagonist predominantly on the first two. READ MORE
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4. Striatal pathways in dyskinesia and dystonia
Abstract : Purposeful and well-coordinated movements depend on the control exerted by dopamine (DA) on the basal ganglia (BG) network. Accordingly, dysfunctions or lesions of the dopaminergic system in the BG can result in an overall poverty and slowness of movement, cardinal features of Parkinson´s disease (PD), or in dyskinesias, exaggerated and involuntary movements resulting from L-DOPA pharmacotherapy. READ MORE
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5. Diversity of striatal interneurons : connectivity and functions
Abstract : Multisensory integration of cortical and thalamic inputs by the striatal network, and its modulation by local acetylcholine and midbrain dopamine, are crucial components of movement control and striatal function. A flexible decision-making process, quick and smooth movement initiation, as well as proper habit-formation would not be possible without properly functioning striatal circuits. READ MORE