Search for dissertations about: "stringent response"
Showing result 1 - 5 of 48 swedish dissertations containing the words stringent response.
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1. The ribosome, stringent factor and the bacterial stringent response
Abstract : The stringent response plays a significant role in the survival of bacteria during different environmental conditions. It is activated by the binding of stringent factor (SF) to stalled ribosomes that have an unacylated tRNA in the ribosomal A-site which leads to the synthesis of (p)ppGpp. READ MORE
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2. Functional studies of Escherichia coli stringent response factor RelA
Abstract : RelA is a ribosome associated multi-domain enzyme, which plays a crucial role in adaptation ofEscherichia coli to nutritional stress as such as amino acid deficiency. It detects the deficiency of aminoacids in the cell by monitoring whether a tRNA at the acceptor site (A-site) of the ribosome is chargedwith amino acid or not. READ MORE
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3. Genetics and Growth Regulation in Salmonella enterica
Abstract : Most free-living bacteria will encounter different environments and it is therefore critical to be able to rapidly adjust to new growth conditions in order to be competitively successful. Responding to changes requires efficient gene regulation in terms of transcription, RNA stability, translation and post-translational modifications. READ MORE
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4. Towards Anti-Virulence Antimicrobials, Discovery and Development of Sortase A Inhibitors and Investigations of Bacterial Phenotypes
Abstract : Antibiotic resistance is an emerging and serious threat to public health. Immediate actions are required to preserve current antibiotics while intensifying research efforts towards the development of new effective therapeutics. READ MORE
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5. The Importance of a Fifth Element in Transcription: Transcriptional Discrimination in Escherichia coli
Abstract : Upon growth arrest of the bacterium Escherichia coli, RNA polymerase (Es70) is redirected from transcribing genes encoding the protein synthesizing system (PSS) to those involved in maintenance and stress resistance. The small nucleotide ppGpp, which is directly targeting Es70, is a key regulatory molecule required for this response. READ MORE