Search for dissertations about: "stroke and gliosis"

Found 4 swedish dissertations containing the words stroke and gliosis.

  2. 1. Regeneration in the adult brain after focal cerebral ischemia : exploration of neurogenesis and angiogenesis

    Author : Wei Jiang; Jukka Jolkkonen; Umeå universitet; []
    Keywords : LANTBRUKSVETENSKAPER; AGRICULTURAL SCIENCES; neurogenesis; angiogenesis; rats; mice; gliosis; BrdU; CBF; protein synthesis; ATP; penumbra; reperfusion; VEGF; 3-D confocal; photothrombosis; MCAO; Medicine; Medicin;

    Abstract : Background: Ischemic stroke ranks as the third major cause of clinical mortality and the leading cause of handicap in adults. Each year, stroke occurs in about 30,000 Swedes. The severity of an acute ischemic stroke depends mainly on the degree and duration of local cerebral blood flow (lCBF) reduction. READ MORE

  4. 2. Reactive gliosis in the injured brain: The effect of cell communication and Nrf2-mediated cellular defence

    Author : Heléne Andersson; Göteborgs universitet; []
    Keywords : Keywords: astrocyte; gap junction; Hmox1; microglia; Nrf2; Nqo1; oxidative stress; reactive gliosis;

    Abstract : Stroke and other brain injuries trigger an extensive glial cell response referred to as reactive gliosis. Reactive gliosis is characterized by hypertrophic and proliferating astrocytes, proliferating microglia and NG2-positive cells, which eventually form a bordering glial scar around the damaged area. READ MORE

  5. 3. In vivo responses of neural progenitor cells to extracellular matrix signaling under pathological conditions

    Author : Reza Motalleb; Göteborgs universitet; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Peptide Amphiphiles; Biomaterial; Tenascin - C; RGDS; RHAMM; Reactive Gliosis; Rostral Migratory Stream; Extracellular Matrix;

    Abstract : The adult brain has an inherently low capacity for tissue regeneration, and neurons lost to disease or injuries are normally not replaced. This becomes especially apparent when stroke or brain trauma occurs. The discovery of neurogenesis and neural stem cells in the adult brain has opened up new avenues for treatment of the injured brain. READ MORE

  6. 4. tPA mediated activation of PDGF-C/PDGFRα signaling in the CNS

    Author : Christina Stefanitsch; Karolinska Institutet; Karolinska Institutet; []
    Keywords : ;

    Abstract : The platelet derived growth factors (PDGFs) and their tyrosine kinase receptors play an essential role during development, in adult tissue homeostasis and in several pathological events. PDGF-CC, a ligand for PDGFRα, is secreted as an inactive dimer. READ MORE