Search for dissertations about: "stromal cell-derived factor-1"

Found 4 swedish dissertations containing the words stromal cell-derived factor-1.

  2. 1. Generation of Dopaminergic Neurons from Human Embryonic Stem Cells

    Author : Tandis Vazin; Joakim Lundeberg; Ernest Arenas; KTH; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Human; dopaminergic; embryonic stem cells; differentiation; stromal cells; PA6 cells; dopamine; neurons; Neuroscience; Neurovetenskap; Neurobiology; Neurobiologi; Molecular neurobiology; Molekylär neurobiologi;

    Abstract : Since the first successful derivation of human embryonic stem cells (hESC), rapid progress has been attained in the development of strategies in differentiation of these cells into various neural lineages, with the fundamental objective of using these cells for replacement and repair of damaged neuronal circuits in the central nervous system (CNS). Of particular interest are midbrain dopaminergic (mDA) neurons, which play a central role in regulation of voluntary movement. READ MORE

  4. 2. Endothelial cells : dysfunction and repair mechanisms

    Author : Elzafir Elsheikh; Karolinska Institutet; Karolinska Institutet; []
    Keywords : Endothelial cells; endothelial progenitor cells; Wegener s granulomatosis; atherosclerosis; myocardial infarction; menstruation cycle; stromal cell-derived factor-1;

    Abstract : Endothelial cells (ECs) are crucial component of the normal vascular wall, providing an interface between the bloodstream and surrounding tissue of the blood vessel wall. Endothelial progenitors cells (EPCs) circulate in the blood and migrate to regions of the circulatory system with injured endothelium and ischemic tissues. READ MORE

  5. 3. Tissue repair in lung disorders

    Author : Annika Andersson Sjöland; Lungbiologi; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES;

    Abstract : The remodeling phase of tissue repair in lung disorders such as idiopathic pulmonary disease, asthma, obliterative bronchiolitis, and after lung transplantation is not well understood. One of the key players in fibrosis is the fibroblast and its progenitor, the fibrocyte. READ MORE

  6. 4. Skeletal muscle responses to physical activity in health and metabolic disease

    Author : Jonathon Alexander Smith; Karolinska Institutet; Karolinska Institutet; []
    Keywords : ;

    Abstract : Sedentary lifestyles, characterised by a lack of physical activity and prolonged periods of sitting, have been linked to reductions in whole-body metabolic flexibility and the increased risk of metabolic diseases, including type 2 diabetes. This can be attributed, at least partially, to the direct negative effects of physical inactivity on skeletal muscle insulin sensitivity, oxidative capacity, and overall metabolic health. READ MORE