Search for dissertations about: "stromal interaction molecule"

Showing result 1 - 5 of 6 swedish dissertations containing the words stromal interaction molecule.

  2. 1. Exploring the interactome of EF-hand proteins

    Author : Mikael Bauer; Biofysikalisk kemi; []
    Keywords : NATURVETENSKAP; NATURAL SCIENCES; EF-hand; calcium; STIM; stromal interaction molecule; secretagogin; Calmodulin; calbindin D28k; protein-protein interactions; zinc; protein array;

    Abstract : EF-hand proteins are central in many cellular processes being the main group of Ca2+-sensing and buffering proteins in the cell. In the work presented in this thesis we study ligand interactions of three EF-hand proteins; calmodulin, calbindin D28k and secretagogin. READ MORE

  4. 2. Human Bone Marrow Microenvironment in Health and Disease

    Author : Sandro Bräunig; Avdelningen för molekylär hematologi; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Hematopoietic microenvironment; Imaging; Myeloproliferative neoplasms; Spatial relationships; acute lymphoblastic leukaemia ALL ; Fibrosis; Mesenchymal stromal cell; Single cell RNA sequencing;

    Abstract : Hematopoietic stem cells (HSCs) are safeguarded from various threats such as stress, injury, or radiationwithin specialized microenvironments or niches within the bone marrow. In this thesis, we investigatedvarious facets of the bone marrow (BM) microenvironment and its critical role in hematopoiesis andrelated disorders. READ MORE

  5. 3. The role of estrogens and the microenvironment in lymphoma progression and drug sensitivity

    Author : Jiyu Guan; Karolinska Institutet; Karolinska Institutet; []
    Keywords : ;

    Abstract : Lymphomas are a group of cancers which originate from lymphatic cells. More than 90% of the lymphomas belong to the group of Non-Hodgkin lymphoma (NHL), which in itself is a non-homogeneous group consisting of different NHL subtypes. Traditionally, lymphomas are not thought of as hormone-related cancers. READ MORE

  6. 4. Soluble intercellular and vascular cell adhesion molecules-1 in lymphoid neoplasms : A clinical and prognostic study of Hodgkin's disease, non-Hodgkin's lymphomas and chronic B-lymphocytic leukaemia

    Author : Ilse Christiansen; Uppsala universitet; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Oncology; Hodgkin s disease; non-Hodgkin s lymphomas; chronic lymphocytic leukaemia; sICAM-1; sVCAM-1; prognostic markers; VCAM-1; ICAM-1; Hodgkin cell lines; Onkologi; Oncology; Onkologi; Clinical Immunology; klinisk immunologi;

    Abstract : The interaction of soluble adhesion molecules with adhesion ligands expressed by immunological cells interfere with the cell-cell adhesion essential for the signal transductions that initiate immunological responses. Preliminary data suggest that soluble adhesion molecules also promote angiogenesis. READ MORE

  7. 5. The role of CD30 in atopic allergy

    Author : Åsa Bengtsson; Karolinska Institutet; Karolinska Institutet; []
    Keywords : CD30; sCD30; CD30L; allergy; atopic dermatitis; T-cell clone; Th1 Th2; placenta; glutathione GSH ; N-acetyl-L-cysteine NAC ;

    Abstract : The 120 kDa CD30 molecule belongs to the tumour necrosis factor (TNF) receptor superfamily and is expressed by activated lymphoid cells. Small populations of CD30+ cells have been detected in the peripheral lymphoid organs, as well as in the thymus. A subset of CD45RO+, so-called memory T cells, also express CD30 after various kind of stimuli. READ MORE