Search for dissertations about: "structural biology"

Showing result 21 - 25 of 625 swedish dissertations containing the words structural biology.

  2. 21. Allosteric control of ALC1-catalyzed nucleosome remodeling

    Author : Laura C. Lehmann; Sebastian Deindl; Stefan D. Knight; Felix Müller-Planitz; Uppsala universitet; []
    Keywords : NATURVETENSKAP; NATURAL SCIENCES; NATURVETENSKAP; NATURAL SCIENCES; ALC1; CHD1L; ATP-dependent chromatin remodeling; nucleosome; allosteric regulation; autoinhibition; macro domain; PARP; ADP-ribosylation; DNA damage; acidic patch; Biology with specialization in Molecular Biology; Biologi med inriktning mot molekylärbiologi; Biology with specialization in Structural Biology; Biologi med inriktning mot strukturbiologi;

    Abstract : The genetic information of eukaryotic cells is packaged inside the nucleus as chromatin. This packaging restricts access to the DNA and therefore represents a barrier for processes such as DNA replication, repair, and gene expression. READ MORE

  4. 22. Structural studies of sugar binding proteins

    Author : Sanjeewani Sooriyaarachchi; Sveriges lantbruksuniversitet; Sveriges lantbruksuniversitet; []
    Keywords : NATURVETENSKAP; NATURAL SCIENCES; NATURVETENSKAP; NATURAL SCIENCES;

    Abstract : Binding proteins, which are themselves non-enzymatic, play an important role in enzymatic reactions as well as non-enzymatic processes by providing a binding platform for the specific recognition of particular molecules. For example, periplasmic binding proteins play a vital role in nutrient uptake in Gram-negative bacteria. READ MORE

  5. 23. Transthyretin and the transthyretin-related protein: A structural study

    Author : Erik Lundberg; A. Elisabeth Sauer-Eriksson; Lennart Sjölin; Umeå universitet; []
    Keywords : NATURVETENSKAP; NATURAL SCIENCES; Transthyretin; Transthyretin-related protein; X-ray crystallography; Protein structure; Amyloidosis; Structural biology; Strukturbiologi;

    Abstract : Transthyretin (TTR) is one of several proteins involved in amyloid disease in humans. Unknown conformational changes of the native state of TTR result in aggregation of TTR molecules into amyloid fibrils, which accumulate in extracellular tissues. This may result in different clinical symptoms, e.g. READ MORE

  6. 24. Structural Studies on PP2A and Methods in Protein Production

    Author : Auður Magnúsdóttir; Pär Nordlund; Herman Van Tilbeurgh; Stockholms universitet; []
    Keywords : NATURVETENSKAP; NATURAL SCIENCES; PP2A; PTPA; B56γ; Protein Production; Structural biology; Strukturbiologi; biokemi; Biochemistry;

    Abstract : PP2A is a major phosphatase in the cell that participates in multiple cell signaling pathways. It is a heterotrimer of a core dimer and variable regulatory subunits. Details of its structure, function and regulation are slowly emerging. Here, the structure of two regulators of PP2A are de-scribed; PTPA and B56γ. READ MORE

  7. 25. Membrane Protein Tailoring and Structural Studies of Leukotriene C4 Synthase

    Author : Daniel Martinez Molina; Pär Nordlund; Robert M. Stroud; Stockholms universitet; []
    Keywords : NATURVETENSKAP; NATURAL SCIENCES; membrane proteins; random mutagenesis; detergent screening; Leukotriene C₄ synthase; IMAC; Structural biology; Strukturbiologi; Biochemistry; biokemi;

    Abstract : Despite a dramatic increase in the number of proteins that have been structurally characterized in recent years, there are still less than 200 unique structures of membrane proteins known today. This is only 1% of the total number of unique protein structures found in structural databases worldwide. READ MORE