Search for dissertations about: "structural genomics"

Showing result 1 - 5 of 31 swedish dissertations containing the words structural genomics.

2. 1. Evolutionary genomics in Corvids : – From single nucleotides to structural variants

   Author : Matthias H. Weissensteiner; Jochen B.W. Wolf; Manfred Grabherr; Kateryna M. Makova; Uppsala universitet; []
   Keywords : NATURVETENSKAP; NATURAL SCIENCES; evolutionary genetics; genomics; population genetics; selection; recombination; chromosomal features; colouration; insertion; deletion; inversion; crow; tandem repeat; transposable element; gene expression;

   Abstract : Heritable genetic variation is the raw material of evolution and can occur in many different forms, from altering single nucleotides to rearranging stretches of millions at once. DNA mutations that result in phenotypic differences are the basis upon which natural selection can act, leading to a shift of the frequency of those mutations. READ MORE

4. 2. A structural genomics pilot project : methods and applications

   Author : Ulrika Ericsson; Pär Nordlund; Elisabeth Sauer-Eriksson; Stockholms universitet; []
   Keywords : TEKNIK OCH TEKNOLOGIER; ENGINEERING AND TECHNOLOGY; Structural biochemistry; Strukturbiokemi;

   Abstract : With the availability of many completely sequenced genomes, scientific research has shifted from genes to the products of the genes, the proteins. Structural genomics groups have been established worldwide, with the objective of determining protein structures on a genome-wide scale. READ MORE

5. 3. Speciation genomics in Ficedula flycatchers

   Author : Madeline Chase; Carina Mugal; Chris Jiggins; Uppsala universitet; []
   Keywords : NATURVETENSKAP; NATURAL SCIENCES; NATURVETENSKAP; NATURAL SCIENCES; recombination; linked selection; selective sweeps; sex chromosomes; structural variation; birds; genome assembly; Biology with specialization in Evolutionary Genetics; Biologi med inriktning mot evolutionär genetik;

   Abstract : Understanding what evolutionary processes have shaped patterns of genomic differentiation between species is a major aim of speciation genomics. However, disentangling the role of different processes that generate similar patterns remains a substantial challenge. READ MORE

6. 4. Applications of Structural Bioinformatics for the Structural Genomics Era

   Author : Marian Novotny; Gerard Kleywegt; Geoff Barton; Uppsala universitet; []
   Keywords : Bioinformatics; structural bioinformatics; fold comparison; left-handed helix; docking; solvent-accessible surface area; register shift; X-ray crystallography; Bioinformatik;

   Abstract : Structural bioinformatics deals with the analysis, classification and prediction of three-dimensional structures of biomacromolecules. It is becoming increasingly important as the number of structures is growing rapidly. READ MORE

7. 5. Protein production and purification in structural genomics

   Author : Martin Hammarström; Per-Åke Nygren; Torleif Härd; Helena Berglund; Herman van Tilbeurgh; KTH; []
   Keywords : TEKNIK OCH TEKNOLOGIER; ENGINEERING AND TECHNOLOGY; Recombinational cloning; Escherichia coli; gene expression; fusion proteins; solubility; circular dichroism; nuclear magnetic resonance; Structural biochemistry; Strukturbiokemi;

   Abstract : The number of gene products available for structural and functional study is increasing at an unprecedented rate as a result of the successful whole genome sequencing projects. Systematic structure determination of proteins on a genomic scale, called structural genomics, can significantly contribute to the field of protein science and to functional annotation of newly identified genes. READ MORE