Search for dissertations about: "structural model"

Showing result 1 - 5 of 1754 swedish dissertations containing the words structural model.

2. 1. Quantifying Structural Change : A Model Based Approach

   Author : Birgitta Törnkvist; Umeå universitet; []
   Keywords : ;

   Abstract : .... READ MORE

4. 2. Improved pharmacometric model building techniques

   Author : Radojka Savic; Mats Karlsson; Siv Jönsson; Matt Hutmacher; Uppsala universitet; []
   Keywords : Model building; Absorption model; Transit compartment model; Nonparametric method; Extended grid method; Semiparametric; Distribution transformation; Shrinkage; Model diagnostics;

   Abstract : Pharmacometric modelling is an increasingly used method for analysing the outcome from clinical trials in drug development. The model building process is complex and involves testing, evaluating and diagnosing a range of plausible models aiming to make an adequate inference from the observed data and predictions for future studies and therapy. READ MORE

5. 3. Transthyretin and the transthyretin-related protein: A structural study

   Author : Erik Lundberg; A. Elisabeth Sauer-Eriksson; Lennart Sjölin; Umeå universitet; []
   Keywords : NATURVETENSKAP; NATURAL SCIENCES; Transthyretin; Transthyretin-related protein; X-ray crystallography; Protein structure; Amyloidosis; Structural biology; Strukturbiologi;

   Abstract : Transthyretin (TTR) is one of several proteins involved in amyloid disease in humans. Unknown conformational changes of the native state of TTR result in aggregation of TTR molecules into amyloid fibrils, which accumulate in extracellular tissues. This may result in different clinical symptoms, e.g. READ MORE

6. 4. Stochastic model updating and model selection with application to structural dynamics

   Author : Majid Khorsand Vakilzadeh; Chalmers tekniska högskola; []
   Keywords : TEKNIK OCH TEKNOLOGIER; ENGINEERING AND TECHNOLOGY; Finite element model; Bayesian model selection; Bayesian model updating; stochastic simulation; Bootstrapping; Subspace system identification; Uncertainty quantification;

   Abstract : Uncertainty induced by our incomplete state of knowledge about engineering systems and their surrounding environment give rise to challenging problems in the process of building predictive models for the system behavior. One such challenge is the model selection problem, which arises due to the existence of invariably multiple candidate models with different mathematical forms to represent the system behavior, and so there is a need to assess their plausibility based on experimental data. READ MORE

7. 5. Membrane Protein Tailoring and Structural Studies of Leukotriene C4 Synthase

   Author : Daniel Martinez Molina; Pär Nordlund; Robert M. Stroud; Stockholms universitet; []
   Keywords : NATURVETENSKAP; NATURAL SCIENCES; membrane proteins; random mutagenesis; detergent screening; Leukotriene C₄ synthase; IMAC; Structural biology; Strukturbiologi; Biochemistry; biokemi;

   Abstract : Despite a dramatic increase in the number of proteins that have been structurally characterized in recent years, there are still less than 200 unique structures of membrane proteins known today. This is only 1% of the total number of unique protein structures found in structural databases worldwide. READ MORE