Search for dissertations about: "structure of glycosaminoglycans"

Showing result 1 - 5 of 21 swedish dissertations containing the words structure of glycosaminoglycans.

  2. 1. Studies of Glycosaminoglycan Interactions - Surface Immobilization Strategies and Biosensing Applications

    Author : Noomi Altgärde; Chalmers tekniska högskola; []
    Keywords : NATURVETENSKAP; NATURAL SCIENCES; TEKNIK OCH TEKNOLOGIER; ENGINEERING AND TECHNOLOGY; NATURVETENSKAP; NATURAL SCIENCES; glycosaminoglycans; interaction studies; growth factor; QCM-D; virus glycoprotein; SPR; surface immobilization;

    Abstract : Many important biological functions of glycosaminoglycans (GAGs) have been highlighted in research literature during recent years. GAGs often serve as function-bearing structural elements in the extracellular matrix (ECM), but are also constituents of the cell membrane. GAGs take part in various biological mechanisms, e.g. READ MORE

  4. 2. Interactions between herpes simplex virus type 1 glycoprotein C and cell surface glycosaminoglycans

    Author : Kristina Mårdberg; Göteborgs universitet; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Herpes simplex virus-1; glycoprotein C; virus receptor; glycosaminoglycans; heparan sulfate; chondroitin sulfate;

    Abstract : The cell surface glycosaminoglycan (GAG) heparan sulfate (HS) serves as an initial receptor for herpes simplex virus type 1 (HSV-1) and virus attachment to the HS molecule is mediated by the envelope glycoprotein C (gC). In the first part of this thesis, we aimed to define the HS-binding domain of viral gC. READ MORE

  5. 3. Properties of the glomerular endothelial cell surface layer in vitro and in vivo

    Author : Vincent Fridén; Göteborgs universitet; []
    Keywords : Glomerular filtration; Glomerular endothelial cell surface layer; Proteinuria; Proteoglycans; glycocalyx; glycosaminoglycans; glomerular endothelial cells; permselectivity and glomerular endothelial cell coat;

    Abstract : A healthy kidney produces final urine that is practically devoid of proteins and other physiologically important solutes. Tremendous amounts of fluid are filtered every day through the glomerular filtration barrier which is the actual sieving site in the kidney. READ MORE

  6. 4. Towards cell replacement therapy in Parkinson’s disease. Proteoglycans and Nogo-A as modulators of axonal growth in midbrain dopaminergic neurons

    Author : Zuzanna Kurowska; Neural plasticitet och reparation; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; LUHMES cells; substantia nigra pars compacta; microarray; heparan sulphate 3-O-sulfotransferase; neurocan; midbrain dopaminergic neurons; grafting; embryonic stem cells; proteoglycans; glycosaminoglycans; Nogo-A; cell replacement therapy; Parkinson’s disease;

    Abstract : Parkinson’s disease (PD) is currently the second most common neurodegenerative disorder (after Alzheimer’s disease). PD is diagnosed on its motor symptoms, which include akinesia, bradykinesia, rigidity, postural imbalance and resting tremor. It is well established that the motor symptoms develop due to lack of dopamine in the striatum. READ MORE

  7. 5. Structural and Functional Analyses of Xyloside-primed Glycosaminoglycans

    Author : Andrea Persson; Glykobiologigruppen; []
    Keywords : Glycosaminoglycan; Xyloside; Chondroitin sulfate; Dermatan sulfate; Heparan sulfate; Proteoglycan; Cancer;

    Abstract : Glycosaminoglycans (GAGs) are polysaccharides produced by essentially all mammalian cells. Due to their enormous structural diversity, they are involved in many biological processes both in health and disease, including all stages of tumor progression. READ MORE