Search for dissertations about: "structure of serum albumin"

Showing result 1 - 5 of 30 swedish dissertations containing the words structure of serum albumin.

2. 1. NMR Studies of Bacterial Albumin-Binding Modules

   Author : Maria U Johansson; Biofysikalisk kemi; []
   Keywords : NATURVETENSKAP; NATURAL SCIENCES; Fysikalisk kemi; Biotechnology; Bioteknik; Proteins; enzymology; Proteiner; enzymologi; Physical chemistry; three-helix bundle; protein structure; protein PAB; protein-protein interactions; protein G; protein dynamics; NMR; module shuffling; GA module; evolution; albumin-binding; bacterial surface proteins;

   Abstract : Peptostreptococcus magnus and group C/G streptococci are Gram-positive cocci that are part of the normal flora and reside in more or less the same locations in the host. Protein G of group C/G streptococci was originally described as binding IgGFc of several species and later shown to also bind human serum albumin and albumins from various animal species. READ MORE

4. 2. Evasion and Attack: Structural Studies of a Bacterial Albumin-binding Protein and of a Cephalosporin Biosynthetic Enzyme

   Author : Sara Lejon; Janos Hajdu; Karin Valegård; Martin Noble; Uppsala universitet; []
   Keywords : NATURVETENSKAP; NATURAL SCIENCES; human serum albumin; GA module; albumin-binding; Finegoldia magna; deacetylcephalosporin C acetyltransferase; cephalosporin C; antibiotic; beta-lactam; biosynthesis; Acremonium chrysogenum; X-ray crystallography; Structural biology; Strukturbiologi;

   Abstract : This thesis describes the crystal structures of two proteins in the context of combatting bacterial infections. The GA module is a bacterial albumin-binding domain from a surface protein expressed by pathogenic strains of the human commensal bacterium Finegoldia magna. READ MORE

5. 3. Studies on the heterogeneity, structure and function of bovine serum albumin

   Author : Lars-Olov Andersson; Uppsala universitet; []
   Keywords : NATURAL SCIENCES; NATURVETENSKAP;

   Abstract : .... READ MORE

6. 4. Rational and Combinatorial Engineering of Affinity Proteins Towards Therapeutical Applications

   Author : Johan Seijsing; Torbjörn Gräslund; Uhlén Mathias; Inger Sandlie; KTH; []
   Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; NATURVETENSKAP; NATURAL SCIENCES; neonatal Fc receptor; FcRn; affibody molecule; immunoglobulin G IgG ; serum albumin SA ; albumin binding domain ABD ; half-life extension; blocking; autoimmune disease; pH-dependence; GAD67; GAD-1; gene therapy; Parkinson’s disease; zinc finger based artificial transcription factor; Biotechnology; Bioteknologi;

   Abstract : Protein engineering has had an immense impact on the development of biological drugs, including replacement therapies with engineered versions of insulin or factor VIII to treat diabetes or bleeding disorders, and monoclonal antibodies to treat cancer and various other malignancies. Now, with the next generation of treatment modalities coming up, including monoclonal reagents based on alternative scaffolds, gene and cell therapies, the importance of protein engineering to tailor-make these treatments is likely to increase further. READ MORE

7. 5. Protein-Surfactant Interactions Phase Behaviour and Phase Structure

   Author : Anna Karin Morén; Fysikalisk kemi; []
   Keywords : NATURVETENSKAP; NATURAL SCIENCES; Phase equilibria; Protein-surfactant interactions; Gel; Precipitate; Solution; Lysozyme; b-lactoglobulin; Ovalbumin; Bovine serum albumin; Dodecyltrimethylammonium chloride; Sodium alkylsulphates; NMR; Cryo-TEM; Physical chemistry; Fysikalisk kemi;

   Abstract : Protein-surfactant interactions in water are investigated by following the phase equilibria for protein-surfactant pairs whose constituents carry both opposite and the same sign of charge. The concentration ranges studied are: 0-20 wt% protein, 0-20 wt% surfactant, and 80-100 wt% water. READ MORE