Search for dissertations about: "study of drug on melanoma cancer"

Showing result 11 - 15 of 16 swedish dissertations containing the words study of drug on melanoma cancer.

  2. 11. p53 transcriptional activity as a tool to uncover novel and diverse druggable targets in cancer

    Author : Marcus James Graeme Watson Ladds; Karolinska Institutet; Karolinska Institutet; []
    Keywords : ;

    Abstract : The transcription factor p53 is one of the most studied tumour suppressors with over 90 000 publications in PubMed referring to the protein. It is also the most frequently mutated gene across all cancer types with around 50% of cancers presenting as mutant p53, and when it is not mutated, it is frequently inactivated to circumvent its tumour suppressor function. READ MORE

  4. 12. Beta-arrestins in cancer : linking pro-tumorigenic extracellular activated signaling with the tumor suppressor p53 pathway

    Author : Naida Suleymanova; Karolinska Institutet; Karolinska Institutet; []
    Keywords : ;

    Abstract : The IGF-1R is an important player in cancer development that maintains the malignant phenotype by inducing cell proliferation, survival, transformation, motility and invasiveness. Activation of IGF-R results in its Mdm2-dependent ubiquitination and degradation followed by MAPK signaling. READ MORE

  5. 13. Cisplatin induced ototoxicity : pharmacokinetics, prediction and prevention

    Author : Andreas Ekborn; Karolinska Institutet; Karolinska Institutet; []
    Keywords : Cisplatin; ototoxicity; pharmacokinetics; monohydrated complex of cisplatin; protection;

    Abstract : Cisplatin is an anticancer drug used against a number of malignancies e.g. testicular cancer, ovarian cancer and some paediatric malignancies. The main dose limiting side effects of cisplatin are oto- and neurotoxicity. READ MORE

  6. 14. Cutaneous lupus erythematosus : epidemiology, association with SLE and comorbidity

    Author : Carina Grönhagen; Karolinska Institutet; Karolinska Institutet; []
    Keywords : ;

    Abstract : Lupus erythematosus (LE) is a disease that includes a broad spectrum of symptoms, from localized cutaneous LE (CLE) to severe systemic LE (SLE). Based on histopathological changes, the skin manifestations of LE can be divided into LE-specific (=CLE) and LE-non-specific manifestations. READ MORE

  7. 15. Dihydroorotate dehydrogenase : new insights into an old target

    Author : Gergana Popova; Karolinska Institutet; Karolinska Institutet; []
    Keywords : ;

    Abstract : Purine and pyrimidine nucleotides are important for both biosynthetic and regulatory pathways in cells. As constituents of the DNA and RNA molecules, the requirements for nucleotides in actively dividing cells are increased. READ MORE