Search for dissertations about: "subcellular localization."

Showing result 1 - 5 of 110 swedish dissertations containing the words subcellular localization..

  2. 1. Antibody-based subcellular localization of the human proteome

    Author : Marie Skogs; Emma Lundberg; Hans Blom; Cecilia Williams; KTH; []
    Keywords : NATURVETENSKAP; NATURAL SCIENCES; Human proteome; Subcellular localization; Organelles; Immunofluorescence; Fixation; Permeabilization; Antibody validation; Bioteknologi; Biotechnology;

    Abstract : This thesis describes the use of antibodies and immunofluorescence for subcellular localization of proteins. The key objective is the creation of an open-source atlas with information on the subcellular location of every human protein. READ MORE

  4. 2. Towards subcellular localization of the human proteome using bioimaging

    Author : Charlotte Stadler; Emma Lundberg; Carolina Wählby; KTH; []
    Keywords : NATURVETENSKAP; NATURAL SCIENCES; Antibody; antibody validation; automated image analysis; automated microscopy; cell line; confocal microscopy; fixation; green fluorescent protein GFP ; immunofluorescence IF ; organelle; protein expression; siRNA; subcellular localization;

    Abstract : Since the publication of the complete sequence of the human genome in 2003 there has been great interest in exploring the functions of the proteins encoded by the genes. To reveal the function of each and every protein, investigation of protein localization at the subcellular level has become a central focus in this research area, since the localization and function of a protein is closely related. READ MORE

  5. 3. Leukotriene C4 synthase : studies on oligomerization and subcellular localization

    Author : Jesper Svartz; Mats Söderström; Sven Hammarström; Colin Funk; Linköpings universitet; []
    Keywords : MEDICINE; MEDICIN;

    Abstract : Leukotrienes (LTs) are polyunsaturated fatty acid derivatives formed by oxygenation of arachidonic acid via the 5-lipoxygenase (5-LO) pathway. Upon activation of inflammatory cells 5-LO is translocated to the nuclear envelope where it converts arachidonic acid to the unstable epoxide LTA4. READ MORE

  6. 4. Large-scale prediction of protein subcellular localization : sequence-based methods and applications

    Author : Olof Emanuelsson; Alfonso Valencia; Stockholms universitet; []
    Keywords : NATURVETENSKAP; NATURAL SCIENCES; NATURVETENSKAP; NATURAL SCIENCES; Biophysics; Biofysik; Biochemistry; Biokemi; Biophysics; biofysik;

    Abstract : .... READ MORE

  7. 5. Subcellular localization and signalling of Brutons tyrosine kinase (Btk)

    Author : Leonardo Vargas-Vallejo; Karolinska Institutet; Karolinska Institutet; []
    Keywords : B-cells; Brutons tyrosine kinase; X-linked agammaglobulinemia; pleckstrin homology domain; cytoskeleton; nucleocytoplasmic shuttling; caveolin-1; ubiquitin; SUMO-1.;

    Abstract : Brutons tyrosine kinase (Btk) is a non-receptor tyrosine kinase related to the Src family of kinases. Mutations in various parts of the gene have been shown to cause X-linked agammaglobulinemia (XLA), a primary immunodeficiency in humans, characterized by a defect in B-cell development. READ MORE