Search for dissertations about: "subclone"

Showing result 1 - 5 of 7 swedish dissertations containing the word subclone.

  2. 1. Genomic instability and genetic heterogeneity in neuroblastoma tumours

    Author : Niloufar Javanmardi; Göteborgs universitet; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Neuroblastoma tumour; subclone; mutation; relapse; deep sequencing; tumour supressor gene;

    Abstract : Neuroblastoma (NB), a tumour of the sympathetic nervous system and the most common malignant disease of early childhood, is responsible for 9% of paediatric cancer related deaths. Aggressive NB still constitutes a major clinical problem with survival rates of about 35%. READ MORE

  4. 2. Recurrent infection with Extended-Spectrum Beta-Lactamase (ESBL) -producing Enterobacteriaceae

    Author : Anna Lindblom; Göteborgs universitet; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; ESBL; E. coli; recurrent infection; UTI; AMR; phylogroup; fimH30Rx;

    Abstract : Infections with Extended-Spectrum Beta-Lactamase (ESBL)-producing Enterobacteriaceae (EPE) are increasing globally. The most common EPE are the gut pathogens Escherichia coli (ESBL-E. coli) and Klebsiella pneumoniae (ESBL-K. pneumoniae). READ MORE

  5. 3. Drug transport and metabolism in in vitro models of the human intestine : By Shamsi D. Raeissi

    Author : Shamsi D. Raeissi; Uppsala universitet; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Pharmacy; FARMACI; PHARMACY; FARMACI; galenisk farmaci; Pharmaceutics;

    Abstract : The objective of this thesis was to study the mechanisms of drug transport and metabolism in two different in vitro models of the human intestine: monolayers of human intestinal epithelial cell lines and intestinal microsomes. The first part of the thesis shows that Caco-2 cell monolayers are a good model for mechanistic studies of drug transport. READ MORE

  6. 4. Molecular Interrogation and Functional Studies of Acute Leukemia

    Author : Axel Hyrenius Wittsten; Avdelningen för klinisk genetik; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Acute leukemia; KMT2A; Cooperating Lesions; Clonal Relationship; Genomic Profiling; Fusion Genes;

    Abstract : Hematological malignancies are defined by their underlying genetic alterations, many of which are used to diagnose patients to classify them to different risk groups that dictate the therapy given. Recent advances in high-throughput sequencing have highlighted the presence of co-occurring genetic lesions and that they may form distinct genetic clones that evolve throughout disease progression. READ MORE

  7. 5. Role of tartrate-resistant acid phosphatase in bone remodeling

    Author : Laia Mira-Pascual; Karolinska Institutet; Karolinska Institutet; []
    Keywords : ;

    Abstract : Tartrate-resistant acid phosphatase is a metalloenzyme that exists as two isoforms: the monomeric TRAP 5a and the proteolytically cleaved TRAP 5b, responsible for phosphatase activity, which is highly expressed in osteoclasts (OCs). TRAP 5b has been used as a serum marker of bone resorption, as it correlates with the absolute number of OCs and with resorption markers such as CTX-I. READ MORE