Search for dissertations about: "subpopulation"

Showing result 1 - 5 of 184 swedish dissertations containing the word subpopulation.

  2. 1. Across Borders : A Histological and Physiological Study of the Subthalamic Nucleus in Reward and Movement

    Author : Nadine Schweizer; Åsa Wallén-Mackenzie; Dai Stephens; Uppsala universitet; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; subthalamic nucleus; STN; basal ganglia; locomotion; hyperlocomotion; rearing; ventral tegmental area; VTA; dopamine; glutamate; vesicular glutamate transporter 2; Vglut2; Parkinson s disease; deep brain stimulation; subpopulation; conditional knock-out; optogenetic; co-expression; in situ hybridization; self-administration; reward behavior; mouse genetics;

    Abstract : The basal ganglia are the key circuitry controlling movement and reward behavior. Both locomotion and reward-related behavior are also modified by dopaminergic input from the substantia nigra and the ventral tegmental area (VTA). READ MORE

  4. 2. Formation and Relevance of Platelet Subpopulations

    Author : Anna Södergren; Sofia Ramström; Karin Öllinger; Riitta Lassila; Linköpings universitet; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES;

    Abstract : Platelets are important players in the hemostatic system, acting as guardians of vessel integrity. When they come across a breach in the vessel wall, they quickly adhere to the damaged surface, secrete activating and adhesive compounds from their secretory granules, recruit additional platelets into a growing platelet plug and support the action of the coagulation system. READ MORE

  5. 3. Tumor cell heterogeneity profiling using single-cell analysis

    Author : Emma Jonasson; Göteborgs universitet; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; tumor heterogeneity; single-cell analysis; cancer stem cells;

    Abstract : Cancer is a diverse disease with large variations between tumor types and patients regarding tumor progression and prognosis. Additionally, most individual tumors are heterogeneous, containing subpopulations of cells with various characteristics. READ MORE

  6. 4. The Impact of Pancreatic Islet Vascular Heterogeneity on Beta Cell Function and Disease

    Author : Sara Ullsten; Per-Ola Carlsson; Joey Lau; Sara Bohman; Rebecca L. Hull; Uppsala universitet; []
    Keywords : Pancreatic islets; heterogeneity; islet vascularity; blood flow; islet transplantation; islet amyloid; insulitis; type 1 diabetes; beta cell proliferation; Medicinsk vetenskap; Medical Science;

    Abstract : Diabetes Mellitus is a group of complex and heterogeneous metabolic disorders characterized by hyperglycemia. Even though the condition has been extensively studied, its causes and complex pathologies are still not fully understood. The occurring damage to the pancreatic islets is strikingly heterogeneous. READ MORE

  7. 5. Dynamics of inbreeding and genetic rescue in a small population

    Author : Malin Hasselgren; Karin Norén; Carles Vilà; Stockholms universitet; []
    Keywords : NATURVETENSKAP; NATURAL SCIENCES; inbreeding; inbreeding depression; genetic rescue; fitness; genomics; conservation genetics; mutational load; arctic fox; pedigree; gene flow; zoologisk ekologi; Animal Ecology;

    Abstract : Isolation at small population size can reduce individual fitness and impede population growth caused by inbreeding and genetic drift (i.e. inbreeding depression). Inbreeding depression can however be circumvented by gene flow from unrelated individuals through masking of recessive deleterious alleles and contribute to population persistence (i. READ MORE