Search for dissertations about: "substance P"

Showing result 1 - 5 of 181 swedish dissertations containing the words substance P.

  1. 1. Substance P Endopeptidase Purification and Characterizataion of Enzyme Activity and Evaluation of its Function during Stressful Condition

    University dissertation from Uppsala : Acta Universitatis Upsaliensis

    Author : Krister Karlsson; Uppsala universitet.; [2004]
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Pharmacology; Substance P Endopeptidase; Neuropeptide; Central Nervous System; Purification; Drug Dependence; Heat Stress; Farmakologi; MEDICINE Physiology and pharmacology Pharmacological research; MEDICIN Fysiologi och farmakologi Farmakologisk forskning;

    Abstract : The purification and biochemical characterization of the substance P (SP) hydrolyzing enzyme, substance P endopeptidase (SPE), have been carried out; with subsequent orientation in neurobiological fundamental processes involved in opioid dependence, withdrawal, and heat-stress.SPE was purified from rat spinal cord, human spinal cord and cerebrospinal fluid (CSF), rat ventral tegemental area (VTA), and rat hippocampus. READ MORE

  2. 2. Substance P and calcitonin gene-related peptide in sensory neurons : their fragmentation and substance P precursor forms

    University dissertation from Uppsala : Acta Universitatis Upsaliensis

    Author : Pierre Le Grevès; Uppsala universitet.; [1990]
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; PHARMACY; FARMACI;

    Abstract : .... READ MORE

  3. 3. Influences of paratendinous innervation and non-neuronal substance P in tendinopathy studies on human tendon tissue and an experimental model of Achilles tendinopathy

    University dissertation from Umeå : Umeå university

    Author : Gustav Andersson; Umeå universitet.; Umeå universitet.; [2010]
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Achilles tendon; tendinopathy; tendinosis; paratenon; innervation; substance P; neuropeptides; neurokinin-1 receptor; MEDICINE Morphology; cell biology; pathology Morphology Anatomy; MEDICIN Morfologi; cellbiologi; patologi Morfologi Anatomi; anatomi; Human Anatomy;

    Abstract : Pain of the musculoskeletal system is one of the most common reasons for people seeking medical attention, and is also one of the major factors that prevent patients from working. Chronic tendon pain, tendinopathy, affects millions of workers world-wide, and the Achilles tendon is an important structure often afflicted by this condition. READ MORE

  4. 4. Development of Substance P 1–7 Related Peptides and Peptidomimetics Targeting Neuropathic Pain

    University dissertation from Uppsala : Acta Universitatis Upsaliensis

    Author : Anna Skogh; Uppsala universitet.; [2018]
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Substance P 1–7; Peptidomimetics; Solid-phase Peptide Synthesis SPPS ; Palladium catalysis; Carbonylation; Imidazole; Bioisostere; Neuropathic pain; Allodynia; Structure-activity relationships; Medicinal Chemistry; Läkemedelskemi;

    Abstract : The neuropeptide substance P 1–7 (SP1–7, H-Arg1-Pro2-Lys3-Pro4-Gln5-Gln6-Phe7-OH) and its amidated analogue SP1–7 amide, have displayed intriguing effects in experimental models for neuropathic pain acting on a specific, yet unknown SP1–7 target. The aim of this thesis was to design and synthesise SP1–7 related peptides and peptidomimetics, to be used as research tools to study the SP1–7 system, and to serve as drug leads in the neuropathic pain area. READ MORE

  5. 5. Airway allergic inflammation. A role of bone marrow and relationship to substance P

    University dissertation from Göteborg

    Author : Masafumi Tomaki; Göteborgs universitet.; Gothenburg University.; [2000]
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; asthma; eosinophils; bone marrow; T lymphocytes; IL-3; IL-5; GM-CSF; substance P.;

    Abstract : Airway inflammation, along with reversible airway narrowing and airway hyperresponsiveness, is a central pathophysiological feature of bronchial asthma. The airway inflammation in asthma is dominated by eosinophils, cells that originate in the bone marrow. READ MORE