Search for dissertations about: "substance P"

Showing result 11 - 15 of 164 swedish dissertations containing the words substance P.

2. 11. Anabolic Androgenic Steroids : Effects on Neuropeptide Systems in the Rat Brain

   Author : Mathias Hallberg; Fred Nyberg; Pierre Le Grevès; James Zadina; Uppsala universitet; []
   Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Biological research on drug dependence; Anabolic androgenic steroids; Nandrolone decanoate; Substance P; NK1 receptor; Substance P 1-7 ; Endopeptidase; Opioids; Calcitonin gene-related peptide; Radioimmunoassay; Autoradiography; Central nervous system; Rats; Biologisk beroendeforskning; Biological research on drug dependence; Biologisk beroendeforskning;

   Abstract : Anabolic-androgenic steroids (AAS) have been used in clinics for decades. The misuse of AAS has previously been attributed merely to sport athletes, taking AAS with intentions to increase muscle mass, enhance physical performance and to improve results in competitions. READ MORE

4. 12. A study of the structural requirements for receptor recognition of the neuropeptides substance P, neuropeptide Y and galanin

   Author : Claudio Rivera; Stockholms universitet; []
   Keywords : NATURVETENSKAP; NATURAL SCIENCES;

   Abstract : .... READ MORE

5. 13. Renal and parathyroid function in psychiatric patients on lithium treatment

   Author : Hans Bendz; Göteborgs universitet; []
   Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; diabetes insipidus; glomerular filtration rate; hypercalcemia; hyperparathyroidism; lithium; nephrogenic; nephropathy; polyuria;

   Abstract : Aims. To investigate the prevalence and clinical implications of renal and parathyroid morbidity in lithium patients. Patients. Short-term lithium patients (n=162; average 6 treatment years) and long-term patients (n=142; average 19 treatment years) were studied cross-sectionally. READ MORE

6. 14. Studies on the level of substance P and calcitonin gene-related peptide in cerebrospinal fluid of pregnant women and patients with chronic pain and in rat brain after spinal cord injury : Special reference to analytical aspects of neuropeptides

   Author : Zhurong Liu; Uppsala universitet; []
   Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Pharmaceutical biosciences; Substance P; Calcitonin gene-related peptide; Radioimmunoassay; High performance liquidchromatography; Cerebrospinal fluid and chronic pain; Farmaceutisk biovetenskap; Biopharmacy; Biofarmaci; Pharmacognosy; farmakognosi;

   Abstract : Substance P (SP) and calcitonin gene-related peptide (CGRP) are sensory peptides known to be involved innociception and inflammatory processes. It is well demonstrated that the two peptides can be released from spinal cord neurons during inflammation and chronic pain induced by peripheral nerve injury. READ MORE

7. 15. Discovery of Small Peptides and Peptidomimetics Targeting the Substance P 1-7 Binding Site : Focus on Design, Synthesis, Structure-Activity Relationships and Drug-Like Properties

   Author : Rebecca Fransson; Anja Sandström; John S Svendsen; Uppsala universitet; []
   Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; substance P 1-7; peptidomimetics; structure-activity relationship; drug-like properties; phenylalanine; imidazole; MAP aryl amides; carbonylation; Pharmaceutical chemistry; Farmaceutisk kemi; Medicinal Chemistry; Läkemedelskemi;

   Abstract : Biologically active peptides are important for many physiological functions in the human body and therefore serve as interesting starting points in drug discovery processes. In this work the neuropeptide substance P 1–7 (SP1–7, H-Arg-Pro-Lys-Pro-Gln-Gln-Phe-OH), which has been demonstrated to reduce neuropathic pain and attenuate opioid withdrawal symptoms in animal models, has been addressed in a medicinal chemistry program with the overall aim of transforming this bioactive peptide into more drug-like compounds. READ MORE