Search for dissertations about: "substantia nigra"

Showing result 1 - 5 of 133 swedish dissertations containing the words substantia nigra.

  2. 1. On the mechanisms and physiological function of somatodendritic dopamine release in substantia nigra

    Author : Filip Bergquist; Göteborgs universitet; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Calcium channels; dopamine release; microdialysis; rotarod; SNARE; striatum; substantia nigra;

    Abstract : Somatodendritic release of neurotransmitters is a neuronal function that is poorly understood in comparison with the more abundant terminal release. This study aimed at characterising somatodendritic dopamine release in substantia nigra in terms of release mechanisms and possible physiological function in motor control. READ MORE

  4. 2. Neurogenesis in the adult brain from ballyhoo to sobriety

    Author : Helena Frielingsdorf; Institutionen för experimentell medicinsk vetenskap; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; neuropsykologi; neurofysiologi; Neurologi; neurophysiology; neuropsychology; Neurology; Nerve growth factor; acetylcholine; GABA; learning; hippocampus; Neurogenesis; dopamine; substantia nigra;

    Abstract : New neurons are spontaneously generated in two regions of the adult brain, the hippocampus and the subventricular zone/olfactory bulb. The objective of this thesis was to study potential implications for adult neurogenesis in Alzheimer's (AD) and Parkinson's diseases (PD). READ MORE

  5. 3. Cytochrome P450 2E1 - relevance for central dopamine neurotransmission and Parkinson's disease

    Author : Haydeh Niazi Shahabi; Göteborgs universitet; []
    Keywords : cytochrome P450 2E1; dopamine; substantia nigra; polymorphism; alternative splicing;

    Abstract : Introduction: The enzyme cytochrome P450 2E1 (CYP2E1) has been found in dopamine (DA) containing brain regions that are of relevance for Parkinson?s disease (PD), and is known to generate reactive oxygen species (ROS), toxic molecules that have been implicated in the degeneration of DA neurones. In addition, previous investigations have indicated that inhibition of CYP2E1 increases extracellular DA in the substantia nigra, a nucleus which degenerates in PD. READ MORE

  6. 4. Modeling pathophysiological aspects of Parkinson’s disease: Manipulating DA handling and alpha-synuclein expression in the nigrostriatal pathway using viral vectors

    Author : Ayse Ulusoy; Brain Repair and Imaging in Neural Systems (BRAINS); []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Parkinson s disease; adeno-associated virus; dopamine; α-synuclein; tyrosine hydroxylase; RNAinterference; shRNA; substantia nigra; animal models; dyskinesia;

    Abstract : The pathological hallmark of Parkinson’s disease is dopaminergic neurodegeneration in the substantia nigra pars compacta neurons and accumulation of α-synuclein containing aggregates in the surviving neurons. The cause of cell death in Parkinson’s disease and the involvement of α-synuclein in the pathophysiology of the disease are unknown. READ MORE

  7. 5. Dopamine and the regulation of movements - significance of nigral and striatal dopamine release in normal, hemiparkinsonian and dyskinetic rats

    Author : Daniel Andersson; Göteborgs universitet; []
    Keywords : dopamine; substantia nigra; striatum; L-DOPA; dyskinesias; serotonin;

    Abstract : Introduction: The nigrostriatal dopamine (DA) containing neurones are a pivotal component in the basal ganglia, a network that regulates movement. Degeneration of these neurones causes the cardinal symptoms of Parkinson’s disease (PD). READ MORE