Search for dissertations about: "substantia nigra"
Showing result 16 - 20 of 133 swedish dissertations containing the words substantia nigra.
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16. The non-human primate as a model of human parkinsonism
Abstract : The motor deficits seen in Parkinson’s disease (PD) are the result of a loss of catecholaminergic neurons from the substantia nigra (SN) and the associated loss of striatal dopamine. Clinical signs become evident once striatal dopamine levels decline by at least 70-80% and nigral cell numbers by 40%, and worsen with increased duration of the disease. READ MORE
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17. Specific genetic modifications in the CNS - Cell specific expression and gene specific regulation
Abstract : Gene therapy is a promising therapeutic tool for many diseases of the CNS. Lentiviral vectors are particularly attractive since this vector type can transduce both dividing and non-dividing cells, have a relatively large cloning capacity, can sustain long-term transgene expression and have low immunogenicity. READ MORE
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18. On retinoid receptors, Nurr1 and related transcription factors in the CNS
Abstract : It has long been known that retinoids (vitamin A derivatives) are required for normal development and growth; in excess however metabolites such as all-trans retinoic acid are potent teratogens. Retinoids exert their effects through transcription factors known as the retinoic acid receptors (RARam -ß and -y) and retinoid X receptors (RXRa, -ß and -y). READ MORE
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19. Neuronal dysfunction, death and repair in the MPTP model of Parkinson's disease
Abstract : We have used mouse and non-human primate models of Parkinson's Disease to analyze neuronal dysfunction, death and repair in the mammalian brain, utilizing the neurotoxin 1-methyl-4-phenyl1,2,3,6-tetrahydropyridine (MPTP). In a series of experiments we assessed the effects of diethyIdithiocarbamate (DDC) on MPTP toxicity, analyzing striatal and midbrain dopamine levels as well as neuronal loss. READ MORE
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20. Perinatal asphyxia in the rat : a morphological and functional analysis of the dopamine systems and dopamine-mediated behaviours in a novel experimental model
Abstract : Asphyxia during labour in the human being is one of the important paediatric complications which can lead to various degree of injuries in the central nervous system. No efficient therapy is available at present. READ MORE