Search for dissertations about: "substitutions"

Showing result 16 - 20 of 199 swedish dissertations containing the word substitutions.

  2. 16. Evolutionary Approaches to Sequence Alignment

    Author : Marcin Bogusz; Simon Whelan; Jeffrey Thorne; Uppsala universitet; []
    Keywords : NATURVETENSKAP; NATURAL SCIENCES; molecular evolution; multiple sequence alignment; pair hidden Markov models; Biology with specialization in Evolutionary Genetics; Biologi med inriktning mot evolutionär genetik;

    Abstract : Molecular evolutionary biology allows us to look into the past by analyzing sequences of amino acids or nucleotides. These analyses can be very complex, often involving advanced statistical models of sequence evolution to construct phylogenetic trees, study the patterns of natural selection and perform a number of other evolutionary studies. READ MORE

  4. 17. Generic Drug Switch in Epilepsy – Pharmacokinetic and Clinical Aspects

    Author : Patrik Olsson; Helsingborg Kliniska Vetenskaper; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Generic drug; Antiepileptic drugs; Pharmacokinetics; Treatment outcome;

    Abstract : Background and aim: Generic drugs contain the same active ingredients as brand- name drugs, with the advantage of much lower costs. The aim of this thesis was to contribute new knowledge to the ongoing debate on the safety of generic antiseizure drug (ASD) substitutions. There was a particular emphasis on the pharmacokinetic and clinical outcomes. READ MORE

  5. 18. Synthesis of new building blocks for conjugated oligomers

    Author : Fredrik Allared; KTH; []
    Keywords : organic semiconductors; thiophenes; heterocyclic synthesis; dithienothiophene; naphthalene;

    Abstract : This thesis deals with the synthesis of new organicmaterials for electronic applications. Several new ring-formingmethods are employed to construct sulphur heterocycles: Tandemelectrophilic aromatic substitution and acid-catalyzedtransetherification of methoxythiophene, double electrophilicaromatic substitutions with ethane-1, 2-disulphenyl chloride,and also, the reaction of dienes with sulphur dichloride. READ MORE

  6. 19. Prescription – Pollution – Poo – Pandemics - Priorities : Neuraminidase Inhibitors from an Environmental Resistance Development Perspective

    Author : Marie Nykvist; Josef D. Järhult; Mikael Leijon; Uppsala universitet; []
    Keywords : Influenza A virus; neuraminidase inhibitor; resistance; environmental; Mallard; zanamivir; avian influenza;

    Abstract : The natural Influenza A virus (IAV) host is waterfowl. Human IAV is treated with neuraminidase inhibitors (NAIs), which are stockpiled worldwide in case of an IAV pandemic. As the drugs escape regular waste water treatment, they can be detected in river waters. READ MORE

  7. 20. On the molecular mechanisms of the amyloid β-peptide aggregation

    Author : Kalyani Sanagavarapu; NanoLund: Centre for Nanoscience; []
    Keywords : NATURVETENSKAP; NATURAL SCIENCES; protein aggregation; amyloid β-peptide; aggregation kinetics; aggregation mechanism N-terminus; mutations; variants; sequence determinants; ; cross-seeding;

    Abstract : The pathogenesis of Alzheimer’s disease is widely believed to be due to production and deposition of the amyloid β-peptide. Several variants of the Aβ peptide are known to exist in in vivo. Variations include mutations or additional functional groups attached to residue side chains and may affect the aggregation process. READ MORE