Search for dissertations about: "substrate specificity switch"

Showing result 1 - 5 of 8 swedish dissertations containing the words substrate specificity switch.

  2. 1. Rational engineering of esterases for improved amidase specificity in amide synthesis and hydrolysis

    Author : Peter Hendil-Forssell; Mats Martinelle; Romas J. Kazlauskas; KTH; []
    Keywords : TEKNIK OCH TEKNOLOGIER; ENGINEERING AND TECHNOLOGY; Amidase; Biocatalysis; Enzyme; Esterase; Enzyme engineering; Lipase; Substrate specificity; Bioteknologi; Biotechnology;

    Abstract : Biocatalysis is an ever evolving field that uses enzymes or microorganisms for chemical synthesis. By utilizing enzymes that generally have evolved for specific reactions under mild conditions and temperatures, biocatalysis can be a more environmentally friendly option compared to traditional chemistry. READ MORE

  4. 2. Meticulous control of the T3SS of Yersinia is essential for full virulence

    Author : Ann-Catrin Björnfot; Hans Wolf-Watz; Kelly T. Hughes; Umeå universitet; []
    Keywords : NATURVETENSKAP; NATURAL SCIENCES; Yersinia; type III secretion; YscU; substrate specificity switch; heat shock proteins; VagH; methyltransferase; virulence; Molecular biology; Molekylärbiologi; molekylärbiologi; Molecular Biology;

    Abstract : The type III secretion system (T3SS) of pathogenic Yersinia pseudotuberculosis is involved in virulence. The syringe-like secretion system spans both bacterial membranes and is responsible for the ability of Yersinia to transfer toxic proteins (Yop proteins) into the eukaryotic target cell. READ MORE

  5. 3. The molecular basis for substrate recognition and gating in sugar transporters

    Author : Sarah McComas; David Drew; Philip Biggin; Stockholms universitet; []
    Keywords : NATURVETENSKAP; NATURAL SCIENCES; NATURVETENSKAP; NATURAL SCIENCES; membrane transport; sugar transporter; simulations; lipids; antimalarial drugs; biokemi; Biochemistry;

    Abstract : Sugar is a vital sustenance for most forms of life. For a cell to take up sugar, specialized transport proteins embedded into the membrane bilayer known as sugar porters, are required. READ MORE

  6. 4. The Structure-Function Relationship and Evolution of Deoxyribonucleoside Kinases

    Author : Zeeshan Mutahir; Molekylär cellbiologi; []
    Keywords : NATURVETENSKAP; NATURAL SCIENCES;

    Abstract : The synthesis of deoxyribonucleoside triphosphates (dNTPs), building blocks of DNA, can be achieved by two different pathways in the cell. One is called de novo synthesis and the other is known as salvage pathway. The de novo pathway involves synthesis of dNTPs by utilizing basic molecules like sugars, amino acids, CO2, NH3, etc. READ MORE

  7. 5. Structure and function of MMP-2 and its inhibitor TIMP-2

    Author : Ari Tuuttila; Karolinska Institutet; Karolinska Institutet; []
    Keywords : Metalloproteinases; MMP-2; TIMP-2; extracellular matrix; crystallography; protein structure;

    Abstract : Animal cells secrete various enzymes capable of degrading the extracellular matrix. One of the most studied groups of these are the matrix metalloproteinases (MMPs). This group of zinc containing endopeptidases consists at present of 26 members and this number is still increasing. READ MORE