Search for dissertations about: "suicide gene therapy"

Showing result 1 - 5 of 10 swedish dissertations containing the words suicide gene therapy.

  2. 1. Gene therapy of neuroblastoma

    Author : Yvonne Arvidsson; Göteborgs universitet; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; neuroblastoma; gene therapy; PNP; ASK1; MASH1; IL-12; GM-CSF; immunotherapy; apoptosis.;

    Abstract : Aims: The survival of children with advanced stages of neuroblastoma has not improved significantly during recent years. Therefore additional treatments based on other modalities need to be developed. The objective of this thesis was to investigate the possibility to develop gene therapy of neuroblastoma. READ MORE

  4. 2. Vector development for suicide gene therapy

    Author : Alar Aints; Karolinska Institutet; Karolinska Institutet; []
    Keywords : Suicide gene therapy; VP22; selection markers; Ouabain resistance gene; GvHD; retroviral gene transfer;

    Abstract : Gene therapy is used to treat conditions that arise from errors in the genetic makeup of cells either congenital diseases resulting from a deletion or mutation in a gene or malignant diseases where genetic regulation mechanisms have been deranged. Suicide gene therapy is one of several gene therapeutic approaches to treat cancer. READ MORE

  5. 3. Optimization of suicide gene therapy in stem cell transplantation with special reference to the selection marker OuaSelect

    Author : Alexandra Treschow; Karolinska Institutet; Karolinska Institutet; []
    Keywords : Gene therapy; cell selection; suicide gene; cancer; immunotherapy; viral vectors; thymidine kinase; Na ; K -ATPase;

    Abstract : For many patients suffering from leukemia and other hematological malignancies, allogeneic hematopoietic stem cell transplantation (HSCT) represents the only curative approach. However, an optimal HSCT procedure is yet to be developed. Transplant-related morbidity and mortality are severe complications arising from this treatment modality. READ MORE

  6. 4. Neural stem cell-mediated enhanced gene therapy of malignant gliomas using a novel plant thymidine kinase

    Author : Zahidul Khan; Karolinska Institutet; Karolinska Institutet; []
    Keywords : Malignant glioma; suicide gene therapy; bystander effect; gap junction; neural stem cell; 4-phenylbutyrate; epigenetics; cell differentiation;

    Abstract : Malignant gliomas are the most common brain tumors in adults. Approximately, 190,000 new patients are diagnosed with malignant gliomas worldwide every year. Unfortunately, the prognosis of malignant gliomas still remains very poor, despite advances in management. READ MORE

  7. 5. Evaluation of the deoxyribonucleoside kinase of Drosophila melanogaster (Dm-dNK) as a suicide gene for treatment of solid tumors

    Author : Xinyu Zheng; Karolinska Institutet; Karolinska Institutet; []
    Keywords : ;

    Abstract : Nucleoside kinases from several species are investigated as "suicide genes" for treatment of malignant tumors. The transfer of the gene encoding herpes simplex virus type-1 thymidine kinase (HSV-1 TK) into malignant cells and subsequent treatment with ganciclovir is one of the most commonly studied strategies of suicide gene therapy. READ MORE