Search for dissertations about: "suicide gene"

Showing result 1 - 5 of 24 swedish dissertations containing the words suicide gene.

2. 1. Epigenetic dysregulation in relation to psychiatric traits in adolescence and adulthood

   Author : Adrian Desai Boström; Helgi B. Schiöth; Daniel Nätt; Uppsala universitet; []
   Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; methylome-wide; DNA methylation; hypersexual disorder; microRNA; oxytocin signaling; psychiatry; hsa-miR-4456; microRNA-4456; MIR4456; epigenetic dysregulation; microRNA expression; gene target prediction; epigenetics; suicide; suicide attempt; HPA axis; CRH gene; Epigenetics; Methylation; Adolescent depression; MIR4646; methylome-wide association study; Omega-3; mQTL analysis; GAD1; HDAC3; DAWBA;

   Abstract : Epigenetics has evolved into a key research focus in the field of psychiatry. DNA methylation is the most researched epigenetic mechanism. In paper I-III, 130 and 93 adolescents were randomly recruited at two separate intervals. READ MORE

4. 2. Vector development for suicide gene therapy

   Author : Alar Aints; Karolinska Institutet; Karolinska Institutet; []
   Keywords : Suicide gene therapy; VP22; selection markers; Ouabain resistance gene; GvHD; retroviral gene transfer;

   Abstract : Gene therapy is used to treat conditions that arise from errors in the genetic makeup of cells either congenital diseases resulting from a deletion or mutation in a gene or malignant diseases where genetic regulation mechanisms have been deranged. Suicide gene therapy is one of several gene therapeutic approaches to treat cancer. READ MORE

5. 3. Gene therapy of neuroblastoma

   Author : Yvonne Arvidsson; Göteborgs universitet; []
   Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; neuroblastoma; gene therapy; PNP; ASK1; MASH1; IL-12; GM-CSF; immunotherapy; apoptosis.;

   Abstract : Aims: The survival of children with advanced stages of neuroblastoma has not improved significantly during recent years. Therefore additional treatments based on other modalities need to be developed. The objective of this thesis was to investigate the possibility to develop gene therapy of neuroblastoma. READ MORE

6. 4. BDNF, impulsiveness and avoidant focused coping in suicide attempters

   Author : LIVIA AMBRUS; Lund Psykiatri; []
   Keywords : BDNF; Aviodant coping; Suicide Attempters; HPA axis; Impulsvieness; BDNF; Avoidant focused coping; HPA axis; attempted suicide; impulsiveness;

   Abstract : Brain-derived neurotrophic factor (BDNF) is an important protein for neuroplasticity and neurogenesis. In this thesis the role of BDNF, in suicidal behaviour was investigated with focus on possible risk factors for suicidal behaviour such as avoidant focused coping, dysfuntional personality traits like impulsiveness and hyperactivity of the Hypothalamic-Pituitary-Adrenal (HPA) axis. READ MORE

7. 5. Influence of serotonin-related genes on behavior and body weight

   Author : Jessica Bah Rösman; Göteborgs universitet; []
   Keywords : Serotonin; Genes; anorexia nervosa; premenstrual dysforia; body weight; suicide; polymorphism; HTR2C; SLC6A4; GATA2; HTR3B;

   Abstract : Rationale: The neurotransmitter serotonin has been implicated in the regulation of normal behaviors, including food intake, and attributed importance for a variety of common psychiatric conditions, including major depression, suicidal behavior, eating disorders and premenstrual dysphoria. The purpose of these studies was to explore the possible influence of genetic variation in serotonin-related genes on a) body weight, b) binding capacity of the serotonin transporter in the brain of suicide attempters and c) a disorder for which numerous findings suggest serotonin to play a key role, i. READ MORE