Search for dissertations about: "sulfonamide resistance"

Showing result 1 - 5 of 8 swedish dissertations containing the words sulfonamide resistance.

  2. 1. Microbial Responses to Antibiotics – Stability of Resistance and Extended Potential of Targeting the Folate Synthesis

    Author : Maria Jönsson; Göte Swedberg; Steven Meshnick; Uppsala universitet; []
    Keywords : NATURVETENSKAP; NATURAL SCIENCES; Molecular biology; sulfonamide resistance; macrolide; commensal flora; substrate channeling; folate synthesis; Molekylärbiologi; Molecular biology; Molekylärbiologi;

    Abstract : Resistance to antimicrobials is an increasing problem in the world of today, and develops faster than man can counter. It is therefore of importance to study metabolic pathways in order to develop new antibiotics, but also to understand how resistance spreads and stabilizes in microbial populations. READ MORE

  4. 2. Design and Synthesis of Hepatitis C Virus NS3 Protease Inhibitors : Targeting Different Genotypes and Drug-Resistant Variants

    Author : Anna Karin Belfrage; Anja Sandström; Ulf Ellervik; Uppsala universitet; []
    Keywords : NATURVETENSKAP; NATURAL SCIENCES; NATURVETENSKAP; NATURAL SCIENCES; hepatitis C virus; HCV; NS3 protease inhibitors; structure-activity relationship; 2 1H -pyrazinone; quinazoline; resistance; Pd catalysis; Medicinal Chemistry; Läkemedelskemi; Farmaceutisk vetenskap; Pharmaceutical Science;

    Abstract : Since the first approved hepatitis C virus (HCV) NS3 protease inhibitors in 2011, numerous direct acting antivirals (DAAs) have reached late stages of clinical trials. Today, several combination therapies, based on different DAAs, with or without the need of pegylated interferon-α injection, are available for chronic HCV infections. READ MORE

  5. 3. Identification of novel antibiotic resistance genes through the exploration of mobile genetic elements

    Author : Mohammad Razavi; Göteborgs universitet; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Environment; Metagenomics; Antibiotic resistance; Mobile genetic elements; Insertion sequences; Integron; Resistome; Next-generation sequencing;

    Abstract : Backgrounds and aims: The evolution of multi-resistant pathogens is seriously threatening our ability to provide modern healthcare. Many of the mobile resistance factors in clinics appear to originate from environmental bacteria. READ MORE

  6. 4. Recombinational processes involved in the acquisition of sulfonamide resistance in gram-negative bacteria

    Author : Peter Rådström; Uppsala universitet; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; PHARMACY; FARMACI;

    Abstract : .... READ MORE

  7. 5. Horizontal transmission and mutational adaptation of sulfonamide resistance in pathogenic strains of Neisseria Meningitidis

    Author : Christian Fermér; Uppsala universitet; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; PHARMACY; FARMACI;

    Abstract : .... READ MORE