Search for dissertations about: "sulfonamide"

Showing result 1 - 5 of 20 swedish dissertations containing the word sulfonamide.

  1. 1. C2- and C3-symmetric ligands via ring-opening of aziridines

    University dissertation from Stockholm : Kemi

    Author : Fredrik Lake; KTH.; [2002]
    Keywords : asymmetric catalysis; aziridine; benzaldehyde; diethylzinc; enantionselective; ligand; proazaphosphatrane; ring-opening; sulfonamide; symmetry; titanium; nicronium;

    Abstract : This thesis deals with the design and synthesis of chiralenantiopure nitrogencontaining ligands and the use of theseligands in asymmetric catalysis. A modular synthetic approachto enantiopure nitrogen-containing ligands was developed. Thesynthetic method is based on the ring-opening of activatedchiral aziridines by nitrogen nucleophiles. READ MORE

  2. 2. Design and Synthesis of Inhibitors Targeting the Hepatitis C Virus NS3 Protease Focus on C-Terminal Acyl Sulfonamides

    University dissertation from Uppsala : Acta Universitatis Upsaliensis

    Author : Robert Rönn; Uppsala universitet.; [2007]
    Keywords : Pharmaceutical chemistry; hepatitis C virus; HCV; NS3 protease inhibitor; acyl sulfonamide; bioisostere; palladium; carbonylation; microwave; molybdenum hexacarbonyl; Farmaceutisk kemi;

    Abstract : Hepatitis C is a global health problem that affects approximately 120–180 million people. This viral infection causes serious liver diseases and the therapy available suffers from low efficiency and severe side effects. Consequently, there is a huge unmet medical need for new therapeutic agents to combat the hepatitis C virus (HCV). READ MORE

  3. 3. Microbial Responses to Antibiotics – Stability of Resistance and Extended Potential of Targeting the Folate Synthesis

    University dissertation from Uppsala : Acta Universitatis Upsaliensis

    Author : Maria Jönsson; Uppsala universitet.; [2005]
    Keywords : NATURVETENSKAP; NATURAL SCIENCES; Molecular biology; sulfonamide resistance; macrolide; commensal flora; substrate channeling; folate synthesis; Molekylärbiologi; NATURAL SCIENCES Biology Cell and molecular biology Molecular biology; NATURVETENSKAP Biologi Cell- och molekylärbiologi Molekylärbiologi;

    Abstract : Resistance to antimicrobials is an increasing problem in the world of today, and develops faster than man can counter. It is therefore of importance to study metabolic pathways in order to develop new antibiotics, but also to understand how resistance spreads and stabilizes in microbial populations. READ MORE

  4. 4. Recombinational processes involved in the acquisition of sulfonamide resistance in gram-negative bacteria

    University dissertation from Uppsala : Acta Universitatis Upsaliensis

    Author : Peter Rådström; Uppsala universitet.; [1991]
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; PHARMACY; FARMACI;

    Abstract : .... READ MORE

  5. 5. Horizontal transmission and mutational adaptation of sulfonamide resistance in pathogenic strains of Neisseria Meningitidis

    University dissertation from Uppsala : Acta Universitatis Upsaliensis

    Author : Christian Fermér; Uppsala universitet.; [1996]
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; PHARMACY; FARMACI;

    Abstract : .... READ MORE