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Showing result 1 - 5 of 25 swedish dissertations matching the above criteria.

  2. 1. C2- and C3-symmetric ligands via ring-opening of aziridines

    Author : Fredrik Lake; KTH; []
    Keywords : asymmetric catalysis; aziridine; benzaldehyde; diethylzinc; enantionselective; ligand; proazaphosphatrane; ring-opening; sulfonamide; symmetry; titanium; nicronium;

    Abstract : This thesis deals with the design and synthesis of chiralenantiopure nitrogencontaining ligands and the use of theseligands in asymmetric catalysis. A modular synthetic approachto enantiopure nitrogen-containing ligands was developed. Thesynthetic method is based on the ring-opening of activatedchiral aziridines by nitrogen nucleophiles. READ MORE

  4. 2. Analysis of fluoroalkyl sulfonamide (FASA) based copolymers : An indirect source of non-polymeric PFAS

    Author : Felicia Fredriksson; Leo W. Y. Yeung; Anna Kärrman; Ulrika Eriksson; Robert Letcher; Örebro universitet; []
    Keywords : NATURVETENSKAP; NATURAL SCIENCES; PFAS; FASA-based copolymers; fluorine mass balance; EOF; sludge; TF; earthworm; exposure;

    Abstract : Per- and polyfluoroalkyl substances (PFAS) are an extensive group of anthropogenic compounds and are of global concern due to their negative effects on the environment and humans. Most environmental research reports non-polymeric PFAS, leading to a scarce understanding of polymeric PFAS, despite their large share on the global market. READ MORE

  5. 3. Design and Synthesis of Inhibitors Targeting the Hepatitis C Virus NS3 Protease : Focus on C-Terminal Acyl Sulfonamides

    Author : Robert Rönn; Anders Hallberg; Anja Sandström; Federico Corelli; Uppsala universitet; []
    Keywords : Pharmaceutical chemistry; hepatitis C virus; HCV; NS3 protease inhibitor; acyl sulfonamide; bioisostere; palladium; carbonylation; microwave; molybdenum hexacarbonyl; Farmaceutisk kemi;

    Abstract : Hepatitis C is a global health problem that affects approximately 120–180 million people. This viral infection causes serious liver diseases and the therapy available suffers from low efficiency and severe side effects. Consequently, there is a huge unmet medical need for new therapeutic agents to combat the hepatitis C virus (HCV). READ MORE

  6. 4. Microbial Responses to Antibiotics – Stability of Resistance and Extended Potential of Targeting the Folate Synthesis

    Author : Maria Jönsson; Göte Swedberg; Steven Meshnick; Uppsala universitet; []
    Keywords : NATURVETENSKAP; NATURAL SCIENCES; Molecular biology; sulfonamide resistance; macrolide; commensal flora; substrate channeling; folate synthesis; Molekylärbiologi; Molecular biology; Molekylärbiologi;

    Abstract : Resistance to antimicrobials is an increasing problem in the world of today, and develops faster than man can counter. It is therefore of importance to study metabolic pathways in order to develop new antibiotics, but also to understand how resistance spreads and stabilizes in microbial populations. READ MORE

  7. 5. Recombinational processes involved in the acquisition of sulfonamide resistance in gram-negative bacteria

    Author : Peter Rådström; Uppsala universitet; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; PHARMACY; FARMACI;

    Abstract : .... READ MORE