Search for dissertations about: "sulfonamide"

Showing result 16 - 20 of 25 swedish dissertations containing the word sulfonamide.

  2. 16. Advances in Stereoselective Palladium(ΙΙ)-Catalyzed Oxidative Transformations of Allenes

    Author : Daniels Posevins; Jan-Erling Bäckvall; Troels Skrydstrup; Stockholms universitet; []
    Keywords : NATURVETENSKAP; NATURAL SCIENCES; Synthesis; Palladium Catalysis; Allenes; Biomimetic; Carbocyclization; Borylation; Carbonylation; Oxidation; Heterogeneous; organisk kemi; Organic Chemistry;

    Abstract : Palladium(ΙΙ)-catalyzed carbon-carbon and carbon-heteroatom bond formation via selective C-H bond oxidation constitutes a step-economical and versatile approach towards complex target molecules. This thesis has been focused on the development of new selective palladium(ΙΙ)-catalyzed transformations of allenes under oxidative conditions catalyzed by either homogenous or heterogeneous palladium(ΙΙ) catalysts. READ MORE

  4. 17. Probing Ligand Binding Mechanisms in Insulin-Regulated Aminopeptidases : Computational analysis and free energy calculations of binding modes

    Author : Sudarsana Reddy Vanga; Hugo Gutiérrez-de-Terán; Johan Åqvist; Efstratios Stratikos; Uppsala universitet; []
    Keywords : Docking; Molecular Dynamics; Binding free energy; Linear Interaction Energy; Free Energy Perturbation; Insulin-Regulated Aminopeptidase; Angiotensin IV; Oxytocin; Vasopressin; HA08; Aryl sulfonamides; HFI compounds.;

    Abstract : In recent years insulin-regulated aminopeptidase (IRAP) has emerged as a new therapeutic target for the treatment of Alzheimer’s disease and other memory-related disorders. So far, many potent and specific IRAP inhibitors had been disclosed, including peptides, peptidomimetics, and low-molecular-weight sulfonamides. READ MORE

  5. 18. Design and Synthesis of Hepatitis C Virus NS3 Protease Inhibitors : Targeting Different Genotypes and Drug-Resistant Variants

    Author : Anna Karin Belfrage; Anja Sandström; Ulf Ellervik; Uppsala universitet; []
    Keywords : NATURVETENSKAP; NATURAL SCIENCES; NATURVETENSKAP; NATURAL SCIENCES; hepatitis C virus; HCV; NS3 protease inhibitors; structure-activity relationship; 2 1H -pyrazinone; quinazoline; resistance; Pd catalysis; Medicinal Chemistry; Läkemedelskemi; Farmaceutisk vetenskap; Pharmaceutical Science;

    Abstract : Since the first approved hepatitis C virus (HCV) NS3 protease inhibitors in 2011, numerous direct acting antivirals (DAAs) have reached late stages of clinical trials. Today, several combination therapies, based on different DAAs, with or without the need of pegylated interferon-α injection, are available for chronic HCV infections. READ MORE

  6. 19. Design and Synthesis of Enzyme Inhibitors Against Infectious Diseases : Targeting Hepatitis C Virus NS3 Protease and Mycobacterium tuberculosis Ribonucleotide Reductase

    Author : Johan Gising; Mats Larhed; Anders Karlén; Victor Snieckus; Uppsala universitet; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Medicinal Chemistry; Läkemedelskemi;

    Abstract : Infectious diseases, including hepatitis C and tuberculosis, claim the lives of over 15 million people each year. Hepatitis C is caused by the hepatitis C virus (HCV) which infects the liver and can ultimately result in liver transplantation. HCV is very adaptive as a result of its high mutation rate. READ MORE

  7. 20. Design and Synthesis of Glycomimetics as Selective Galectin Inhibitors

    Author : Mukul Mahanti; Centrum för analys och syntes; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; NATURVETENSKAP; NATURAL SCIENCES; Galectin; Galectin inhibitors; Glycomimentics; Epimeric switch; MD simulation;

    Abstract : In last couple of decades the field of glycobiology has developed rapidly due to the increased understanding of glycans’ abilities to encode biological information, which may have impact on biological event and disease, such as for example tumour growth and inflammation. This development has been accompanied by an increasing focus on drug discovery revolving around a category of carbohydrate-based drugs termed glycomimetics. READ MORE