Search for dissertations about: "sulfonylureas"

Showing result 6 - 10 of 10 swedish dissertations containing the word sulfonylureas.

2. 6. Multicomponent Reactions in 11C/12C Chemistry : – Targeting the Angiotensin II Subtype 2 Receptor

   Author : Marc Stevens; Luke Odell; Mats Larhed; Gunnar Antoni; Sergio Estrada; Ola Åberg; Neil Vasdev; Uppsala universitet; []
   Keywords : NATURVETENSKAP; NATURAL SCIENCES; carbonylation; positron emission tomography; multicomponent reactions; AT2R; 3; 4-dihydroquinazolinone; sulfonyl azides; Farmaceutisk vetenskap; Pharmaceutical Science;

   Abstract : Section 1 of this thesis contains an introduction to method development in organic synthesis, multicomponent reactions, sulfonyl azides, tracer development in 11C chemistry and the biological target.Section 2 describes the use of sulfonyl azides in carbonylative chemistry. Paper I covers development of a diazotransfer protocol. READ MORE

4. 7. Gene expression in human adipose tissue. Studies of leptin and genes selected by expression profiling

   Author : Britt Gabrielsson; Göteborgs universitet; []
   Keywords : obesity; subcutaneous; omental; DNA microarray; sulfonylurea receptor; fibroblast; growth factors; complement system; fibroblast;

   Abstract : Obesity, and in particular the amount of visceral adipose tissue, is correlated to development of type 2diabetes and cardiovascular disease. The aim of this thesis was to study genes expressed in humanadipose tissue that could be involved in regional adipose tissue homeostasis and/or obesity-associateddisease. READ MORE

5. 8. Mechanism of pure glucose-dependent insulinotropic activity of a novel imidazoline compound BL11282

   Author : Vladimir Sharoyko; Karolinska Institutet; Karolinska Institutet; []
   Keywords : Insulin secretion; pancreatic islets; imidazolines; BL11282; arachidonic acid; phospholipase; cytochrome P-450; GLP-1; desensitization; Rhes;

   Abstract : We developed a novel, pure glucose-dependent, insulinotropic imidazoline compound, BL11282, which directly affects the insulin exocytotic machinery and does not block the KATP channel activity. BL11282 does not induce insulin secretion at basal glucose concentrations, whereas it stimulates insulin secretion at an elevated glucose level. READ MORE

6. 9. Lipid‐modifying and glucose-lowering therapies in clinical practice : The impact of guidelines and changing reimbursement schemes

   Author : Billie Pettersson; Lars‐Åke Levin; Per Wändell; Mikael Hoffmann; Lars Weinehall; Linköpings universitet; []
   Keywords : ;

   Abstract : cardiovascular disease, which is still a major cause of death that creates large burdens to society in terms of costs and morbidity. Dyslipidemia and type 2 diabetes mellitus are the main risk factors for cardiovascular disease, and national and international guidelines recommend lipid-modifying and glucose-lowering treatments for prevention. READ MORE

7. 10. Regulation of exocytosis by Ca2+ and cAMP - A study on pancreatic beta- and alpha-cells

   Author : Xiaosong Ma; Institutionen för experimentell medicinsk vetenskap; []
   Keywords : NATURVETENSKAP; NATURAL SCIENCES; Endocrinology; secreting systems; type-2 diabetes; SUR1; Ca2 -channel; glucagon; exocytosis; insulin; diabetology; Endokrinologi; sekretion; diabetologi;

   Abstract : Type-2 diabetes is characterized by impaired insulin secretion associated with excess glucagon release. Exocytosis of insulin- or glucagon-containing granules is initiated by Ca2+-influx through voltage-dependent Ca2+-channels and is modulated by the second messengers such as cAMP. READ MORE