Search for dissertations about: "sumoylation"

Showing result 1 - 5 of 20 swedish dissertations containing the word sumoylation.

  2. 1. Modulation of PDGF receptors function by posttranslational modifications

    Author : Kehuan Wang; Carl-Henrik Heldin; Johan Lennartsson; Natalia Papadopoulos; Jean-Baptiste Demoulin; Uppsala universitet; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; PDGF signaling; receptor tyrosine kinase; ubiquitination; DUB; STAT3; SUMO; SUMOylation; cleavage; autophagy; SQSTM1 p62; LC3; GABARAP; bafilomycin A1; Medicinsk biokemi; Medical Biochemistry; Medical Cell Biology; Medicinsk cellbiologi;

    Abstract : The platelet-derived growth factor receptors (PDGFRs) play important roles in multiple cellular processes including cell survival, cell growth and cell migration. Dysregulation of PDGFRs causes aberrant PDGF signaling, which leads to various diseases. READ MORE

  4. 2. SUMOylation is a post-translational modification regulating skeletal muscle pathophysiology

    Author : Gabriel Antonio Heras Arribas; Karolinska Institutet; Karolinska Institutet; []
    Keywords : ;

    Abstract : The research of this thesis is focused to investigate the role of SUMOylation, a protein post-translational modification reaction, implemented to the skeletal muscle pathophysiology area. SUMOylation is regulated by an enzymatic cascade of coordinated events capable of the reversible attachment of the Small Ubiquitin-like Modifier (SUMO) on to the targeted proteins. READ MORE

  5. 3. Molecular mechanisms of the transcriptional co-activator mastermind-like 1

    Author : Magnus L Hansson; Karolinska Institutet; Karolinska Institutet; []
    Keywords : ;

    Abstract : Gene regulation is a complex process that requires several types of proteins, including chromatin-modifying enzymes, transcription factors, co-activators and co-repressors. We have investigated the molecular mechanisms underlying the action of the co-activator protein MAML1, which was first identified as a transcriptional co-activator for Notch receptors. READ MORE

  6. 4. Role of posttranslational modifications in regulation of Notch and transcriptional coactivator mastermind-like 1

    Author : Anita Popko-Scibor; Karolinska Institutet; Karolinska Institutet; []
    Keywords : ;

    Abstract : The Notch signaling is an evolutionary conserved pathway enabling short range cell-cell interactions, crucial for diverse developmental and physiological processes during embryonic and adult life. The Mastermind-like (MAML) family of transcriptional coactivator proteins has been shown to play an essential role in regulation of Notch-mediated transcription. READ MORE

  7. 5. Ubiquitin, SUMO and PAR : deciphering recruitment signals at DNA damage sites

    Author : Annika Pfeiffer; Karolinska Institutet; Karolinska Institutet; []
    Keywords : ;

    Abstract : Protecting genome integrity is a vital task that is constantly challenged by various genotoxic stresses. Among different types of DNA damage, double-strand breaks (DSBs) constitute a particular threat since they result in the loss of integrity of both complementary DNA strands. READ MORE