Search for dissertations about: "suprachiasmatic"

Showing result 1 - 5 of 7 swedish dissertations containing the word suprachiasmatic.

2. 1. Effects of aging and inflammatory molecules on the suprachiasmatic circadian clock

   Author : Mikael Nygård; Karolinska Institutet; Karolinska Institutet; []
   Keywords : Circadian; suprachiasmatic; synaptic; inflammation; cytokine; SOCS; interferon; tumor necrosis factor; neuron; firing;

   Abstract : The suprachiasmatic nucleus (SCN) is considered the master circadian pacemaker in the mammalian brain and is vital for generating physiological and behavioral circadian rhythms. During aging and inflammatory conditions the circadian system is frequently affected, but relatively little is known about the mechanisms underlying such effects. READ MORE

4. 2. Circadian rhythm dysfunction in the suprachiasmatic nucleus : effects of Trypanosoma brucei brucei infection and inflammatory cytokines

   Author : Gabriella B Lundkvist; Karolinska Institutet; Karolinska Institutet; []
   Keywords : Suprachiasmatic nucleus; slice; Trypanosoma brucei; sleeping sickness; spontaneous firing; rhytm; synaptic activity; GABA; glutamate; AMPA cytokines; sleep regulation; interferon-gamma; tumor necrosis factor-alpha;

   Abstract : Alterations in the mammalian circadian pacemaker, the hypothalamic suprachiasmatic nuclei (SCN), were studied in an experimental rat model of African trypanosomiasis, or sleeping sickness, caused by infections with subspecies of Trypanosoma brucei (T b). Characteristic signs of the disease are marked disturbances in circadian rhythms, such as a fragmentation of the sleep-wake cycle. READ MORE

5. 3. In the right place and at the right time : cellular and functional neuroanatomy of endocannabinoids and neuropeptides

   Author : Joanne Bakker; Karolinska Institutet; Karolinska Institutet; []
   Keywords : ;

   Abstract : A plethora of chemical signals, including endocannabinoids and neuropeptides, enable neuronal communication beyond the classical neurotransmitters. Many of these molecules are also expressed during (early) brain development, helping neurons to mature and neuronal circuits to take form. READ MORE

6. 4. Effects of excess glucocorticoids on neural cell fate : long lasting consequences of adverse prenatal factors

   Author : Mirko Conti; Karolinska Institutet; Karolinska Institutet; []
   Keywords : ;

   Abstract : The developing nervous system is particularly vulnerable to high level of glucocorticoids (GCs). Excess GCs is often associated with decreased birth weight in relation to gestational age, and to increased risk of psychiatric disorders, like depression, later in life. READ MORE

7. 5. Anatomical studies of the dopamine system in the hypothalamus and the pituitary gland

   Author : Arash Hellysaz; Karolinska Institutet; Karolinska Institutet; []
   Keywords : ;

   Abstract : The hypothalamus is a small, evolutionarily conserved brain region, necessary for our survival as individuals and as a species. It collects various sensory inputs, process them to maintain homeostasis and to overcome stressors, and generates outputs that affect the autonomic nervous system, the endocrine system and somatomotor behaviors. READ MORE