Search for dissertations about: "surface marker"

Showing result 1 - 5 of 109 swedish dissertations containing the words surface marker.

  1. 1. Towards specific quantification of exosomes using surface-based sensing

    Author : Deborah Rupert; [2014]
    Keywords : NATURVETENSKAP; NATURAL SCIENCES; NATURVETENSKAP; NATURAL SCIENCES; label-free; surface plasmon resonance.; exosome; binding rate; antibody; concentration; nanoparticle tracking analysis; quantification; liposome; cluster of differentiation 63 CD63 ; diffusion; specific detection; mass transport limited conditions; extracellular vesicles; surface-based biosensor;

    Abstract : When exosomes were first observed in 1967, they were believed to be cell debris until extensive studies demonstrated key biological functionalities related to their composition and formation mechanism. Exosomes are nanometer-sized lipid vesicles of endocytic origin, with a membrane consisting of lipids and proteins and encapsulating a cargo composed of soluble proteins and genetic material. READ MORE

  2. 2. Physical characterization of exosomes and other extracellular vesicles using surface-based sensing

    Author : Deborah Rupert; [2015]
    Keywords : NATURVETENSKAP; NATURAL SCIENCES; NATURVETENSKAP; NATURAL SCIENCES; NATURVETENSKAP; NATURAL SCIENCES; nanoparticle tracking analysis; exosomes; scattering; surface-based biosensing; optical density; cluster of differentiation 63 CD63 ; liposomes; label-free; fluorescence; surface plasmon resonance; Extracellular vesicles; specificity; antibody; lipid content; single particle; quantification; size distribution; optical waveguide microscopy;

    Abstract : Extracellular vesicles (EVs) are hundred of nanometer sized particles secreted by almost all cell types. Exosomes are one type of EVs today intensively investigated due to the increased evidence suggesting that they play important roles as communicating vehicles in a broad range of physiological processes, pathological conditions and disease diagnostics. READ MORE

  3. 3. Microfluidics in Surface Modified PDMS Towards Miniaturized Diagnostic Tools

    University dissertation from Uppsala : Acta Universitatis Upsaliensis

    Author : Sara Thorslund; Uppsala universitet.; [2006]
    Keywords : Materials science; µTAS; micro total analysis system; PDMS; poly dimethylsiloxane ; microfluidics; heparin; blood filtration; on-chip; ESI-MS; desalting; QCM-D; biocompatible; CD4; capillary flow; lab-on-chip; microfabrication; enrichment; point-of-care; hydrophilic; oxidation; Materialvetenskap;

    Abstract : There is a strong trend in fabricating miniaturized total analytical systems, µTAS, for various biochemical and cell biology applications. These miniaturized systems could e.g. gain better separation performances, be faster, consume less expensive reagents and be used for studies that are difficult to access in the macro world. READ MORE

  4. 4. Cardiomyocyte Cell Cycle, Renewal and Isolation

    University dissertation from Cardiovascular Laboratory, Center for Stem Cell Biology, Lund

    Author : Stuart Walsh; Lund University.; Lunds universitet.; [2010]
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; binucleation; Cardiomyocytes; surface marker; troponin-T; mitosis; microarray; cell cycle; FACS;

    Abstract : Heart disease results from the loss of cardiomyocytes following myocardial damage and is a leading cause of death worldwide. Stimulating the endogenous regeneration of cardiomyocytes or isolating them from in vitro culture is an attractive therapeutic strategy. READ MORE

  5. 5. Immunological analysis of the human tumor cell surface : characterization of polypeptides associated with urinary bladder carcinoma

    University dissertation from Stockholm : Stockholm University

    Author : Staffan Paulie; Stockholms universitet.; [1985]
    Keywords : NATURVETENSKAP; NATURAL SCIENCES;

    Abstract : Tumors express antigens characteristic of their malignant phenotype, a fact that has become exploited for the diagnosis of certain types of cancer. As these tumor-associated antigens (TAA) may also provide Information on the molecular mechanisms of tumorogenesls as well as constituting the basis for immunotherapeutlc approaches, much Interest has been focused on the Identification and characterization of TAAs. READ MORE