Search for dissertations about: "swine"

Showing result 1 - 5 of 48 swedish dissertations containing the word swine.

  1. 1. On intestinal ischaemia after aortoiliac surgery : Epidemiological, clinical and experimental studies

    Author : Martin Björck; Uppsala universitet; []
    Keywords : MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Surgery; Ischaemia; intestines; colon; ischaemic colitis; aorta-abdominal; aortic aneurysm-abdominal; aortic rupture; atherosclerosis; postoperative complications; cohort studies; case-control studies; clinical protocols; experimental design; incidence; risk factors; diagnosis; treatment outcome; intra-mucosal pH; pHi; swine; splanchnic circulation; haemodynamics; dobutamine; Kirurgi; Surgery; Kirurgi; Surgery; kirurgi;

    Abstract : An important cause of death among patients undergoing surgery of the abdominal aorta is intestinal ischaemia. In the Swedish Vascular Registry 2930 aortoiliac operations were identified. The complication was studied in a combined cohort and case-control study, and multivariate analysis performed. The incidence of intestinal ischaemia was 2. READ MORE

  2. 2. Intestinal effects of lung recruitment maneuvers

    Author : Jonas Claesson; Ola Winsö; Stefan Lehtipalo; Conny Arnerlöv; Björn Biber; Göran Hedenstierna; Petter Aadahl; Umeå universitet; []
    Keywords : MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; acute lung injury; oleic acid lung injury; ischemia; reperfusion injury; swine; mechanical ventilation; lung recruitment; splanchnic circulation; laser Doppler flowmetry; tissue oxygen tension; microdialysis; lactate; glycerol; Anaesthetics and intensive care; Anestesiologi och intensivvård; lungmedicin; Lung Medicine;

    Abstract : Background and aims: Lung recruitment maneuvers (brief episodes of high airway pressure) are a modern treatment alternative to achieve open lung conditions under mechanical ventilation of patients with acute lung injury. It is well known that positive pressure ventilation with high airway pressures cause negative circulatory effects, and that the effects on regional vascular beds can be even more pronounced than the systemic effects. READ MORE

  3. 3. Lung Transplantation: Clinical and experimental studies

    Author : Leif Eriksson; Lund Lungmedicin och Allergologi; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Respiratory system; Follow up Studies; Vascular Resistance; Intensive Care; Induced; Hypothermia; Swine; Extracorporeal Circulation; Lung Transplantation; Organ Preservation; Andningsorganen; Immunology; serology; transplantation; Immunologi; serologi;

    Abstract : During the past 15 years lung transplantation has been established as a therapeutic option for patients with end-stage pulmonary disease. The results have improved over time and some transplantation centers now show 1-year survival rates above 80%. READ MORE

  4. 4. Olfactory Transfer of Analgesic Drugs After Nasal Administration

    Author : Ulrika Espefält Westin; Erik Björk; Eva Brittebo; Margareta Hammarlund-Udenaes; Paolo Colombo; Uppsala universitet; []
    Keywords : Pharmaceutics; Nasal administration; Olfactory transfer; Olfactory pathways; Central nervous system; Blood-brain barrier; Nasal respiratory mucosa; Olfactory mucosa; Olfactory bulb; Horizontal Ussing chamber; Morphine; Dihydroergotamine; Rat; Mouse; Swine; Autoradiography; Viability; Powder formulations; Galenisk farmaci;

    Abstract : Nasal administration of analgesics for achieving rapid pain relief is currently a topic of great interest. The blood-brain barrier (BBB) restricts access to the central nervous system (CNS) for several central-acting drugs, such as morphine and dihydroergotamine, which results in a substantial effect delay. READ MORE

  5. 5. Models for the Transfer of Drugs from the Nasal Cavity to the Central Nervous System

    Author : Björn Jansson; Erik Björk; Sveinbjörn Gizurarson; Uppsala universitet; []
    Keywords : MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Biopharmacy; Administration; intranasal; Nasal mucosa; Central nervous system; Olfactory bulb; Rat; Mouse; Swine; Cattle; Diffusion chambers; culture; In vitro; Biological models; Biological transport; Dextrans; Dopamine; Gels; Polysaccharides; Autoradiography; Fluorescence microscopy; Biofarmaci; Biopharmacy; Biofarmaci;

    Abstract : The blood-brain barrier restricts the access of many compounds, including therapeutic agents, to the brain. Several human studies indicate that nasal administration of hydrophilic compounds, such as peptides, can bypass the blood-brain barrier. The aims of this thesis were to develop and refine models for this direct nose-to-brain transfer. READ MORE