Search for dissertations about: "synapsin"

Showing result 1 - 5 of 7 swedish dissertations containing the word synapsin.

  2. 1. Coordination of endocytosis at the synaptic periactive zone

    Author : Emma Evergren; Karolinska Institutet; Karolinska Institutet; []
    Keywords : Synapse; endocytosis; clathrin; dynamin; amphiphysin; synapsin; intersectin; actin cytoskeleton; immunogold electron microscopy.;

    Abstract : Neurons in the central nervous system communicate via specialized junctions called synapses. Neurotransmitter-filled vesicles are clustered at these junctions, where they are released in response to synaptic activity. To sustain reliable neurotransmission the synaptic vesicles are recycled locally. READ MORE

  4. 2. Mechanisms underlying sustained synaptic release of glutamate

    Author : Oleg Shupliakov; Karolinska Institutet; Karolinska Institutet; []
    Keywords : synaptic transmission; synaptic vesicle proteins; synapsin; glutamate; glutamine; glutamate uptake; glia; spinal cord; hippocampus; neuromuscular junction; lamprey; crayfish; mouse.;

    Abstract : Fast communication between neurons in the brain is mediated mainly by amino acid transmitters, such as glutamate, GABA and glycine. These transmitters are stored in small synaptic vesicles which undergo exocytosis at synaptic release sites (active zones) in response to action potentials. READ MORE

  5. 3. Intraocular and intracranial transplantation of neural tissue : Studies on hypothalamic and hippocampal neuros

    Author : Hanna Bergman; Pertti Panula; Linköpings universitet; []
    Keywords : MEDICINE; MEDICIN;

    Abstract : Previous studies has demonstrated the possibility to transplant monoaminergic neurons intracranially and to the anterior chamber of the eye, where these neurons continue to develop into functional, transmitter expressing cells. In the present study, investigations were undertaken to examine the development of transplanted hypothalamic and hippocampal neurons in the rat. READ MORE

  6. 4. Development of proteomic methods for studying cerebrospinal fluid proteins involved in Alzheimer´s disease

    Author : Maja Puchades; Göteborgs universitet; []
    Keywords : Alzheimer s disease; cerebrospinal fluid; proteomics; mass spectrometry; biomarkers; synaptic proteins; liquid phase IEF; biomarkers;

    Abstract : Alzheimer's disease (AD) is the most common cause of dementia in western countries. The main neuropathological findings in the AD brain are senile plaques, neurofibrillary tangles and degeneration of neurons and synapses. READ MORE

  7. 5. The N-methyl-D-aspartate receptor subunit NR3A : cloning, expression and interacting proteins

    Author : Maria Eriksson; Karolinska Institutet; Karolinska Institutet; []
    Keywords : ;

    Abstract : This thesis focuses on the subunit NR3A, which together with subunits NR1, NR2A-NR2D and NR3B builds the excitatory glutamate receptor N-methyl-D-aspartate (NMDA). The receptor is most likely a tetramer, containing at least one NR1, probably two NR2 and sometimes one NR3 subunit. READ MORE