Search for dissertations about: "synaptic activation"
Showing result 1 - 5 of 92 swedish dissertations containing the words synaptic activation.
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1. Beyond AMPA and NMDA: Slow synaptic mGlu/TRPC currents : Implications for dendritic integration
Abstract : In order to understand how the brain functions, under normal as well as pathological conditions, it is important to study the mechanisms underlying information integration. Depending on the nature of an input arriving at a synapse, different strategies may be used by the neuron to integrate and respond to the input. READ MORE
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2. Gene therapy for epilepsy: resculpturing synaptic transmission with neuropeptides
Abstract : Intractable seizures and lack of effective antiepileptic drugs (AED) are severe and common conditions affecting many patients with epilepsy. Thus, there is an urgent need to develop new therapies in epilepsy. The search for novel treatments has identified several neuropeptide systems as potential targets for future therapeutic interventions. READ MORE
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3. Synaptic transmission and synaptic plasticity in the mouse striatum
Abstract : The striatum is the major input nucleus of the basal ganglia and can be subdivided into a dorsal part and a ventral part that is also named nucleus accumbens (NAc). The dorsal part is involved in motor control and habit learning whereas the ventral part is mostly associated with rewardmotivated behaviors. READ MORE
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4. Endogenous modulators of hyperexcitability in epilepsy: electrophysiological and optogenetic delineation of neuropeptide Y mechanisms in interneurons
Abstract : Epilepsy is one of the most common neurological disorders worldwide, affecting 1% of the general population, and is characterized by a predisposition for the generation of epileptic seizures. Despite having several different aetiologies, a common underlying cause of epilepsy seems to be an acquired imbalance between excitatory and inhibitory circuits in the brain, which leads to hyperexcitability and appearance of seizures. READ MORE
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5. Plasticity and variation of synaptic responses in hippocampus. Role of AMPA and NMDA receptors
Abstract : It is generally believed that synaptic plasticity in the central nervous system may underlie learning and memory as well as neuronal development. The most wellstudied examples of such synaptic plasticity are long-term potentiation (LTP) andlong-term depression (LTD). READ MORE