Search for dissertations about: "synaptic vesicle proteins"

Showing result 16 - 20 of 24 swedish dissertations containing the words synaptic vesicle proteins.

2. 16. SNAP-25 and Cdk5 as exocytotic regulators : consequences for synaptic function and insulin release

   Author : Jenny Johansson; Karolinska Institutet; Karolinska Institutet; []
   Keywords : ;

   Abstract : The process by which cells release substances through fusion of vesicles with the plasma membrane is called exocytosis. Regulated exocytosis needs to be tightly controlled in order to respond to the large variation in stimuli and demands for release of neurotransmitters, peptides and hormones. READ MORE

4. 17. Dementia Proteomics

   Author : Julia Remnestål; Peter Nilsson; Anna Månberg; Pieter Jelle Visser; KTH; []
   Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Dementia; Proteomics; Alzheimer s disease; Frontotemporal dementia; Antibody array; Suspension bead array; Cerebrospinal fluid; Protein profiling; Biomarker discovery; Bioteknologi; Biotechnology;

   Abstract : The term dementia encompass a number of conditions arising as a consequence of tissue degeneration in the brain. This degeneration is caused by molecular events occurring on a cellular level including inflammation, defective waste disposal and accumulation of insoluble proteins and peptides. READ MORE

5. 18. Visualising neurodegeneration in the living brain : Preclinical evaluation of PET radioligands

   Author : Mengfei Xiong; Stina Syvänen; Sahar Roshanbin; Joakim Bergström; Per Borghammer; Uppsala universitet; []
   Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Positron emission tomography PET ; Alzheimer s disease; Parkinson s disease; SV2A; neurodegeneration; immunotherapy; transgenic mice; Medicinsk vetenskap; Medical Science; Analytical Chemistry; Analytisk kemi; Pharmacology; Farmakologi; Molekylär medicin; Molecular Medicine;

   Abstract : With an ageing population, the number of people suffering from Alzheimer’s disease (AD) and Parkinson’s disease (PD) escalates yearly. Pathological hallmarks of AD and PD include aggregated proteins and synaptic dysfunction. READ MORE

6. 19. Proteomics Studies of Subjects with Alzheimer’s Disease and Chronic Pain

   Author : Payam Emami Khoonsari; Kim Kultima; Martin Ingelsson; Magnus Wetterhall; Ann Brinkmalm; Uppsala universitet; []
   Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Bioinformatics; microservices; biomarkers; Alzheimer s disease; chronic pain; fibromyalgia; neuropathic pain; spinal cord stimulation; cloud computing; proteomics; metabolomics; software; workflows; data analysis; mass spectrometry; Bioinformatics; Bioinformatik; Neurology; Neurologi; Geriatrics; Geriatrik;

   Abstract : Alzheimer’s disease (AD) is a neurodegenerative disease and the major cause of dementia, affecting more than 50 million people worldwide. Chronic pain is long-lasting, persistent pain that affects more than 1.5 billion of the world population. READ MORE

7. 20. Investigation of the intercellular transmission of α-synuclein, amyloid-β and TDP-43

   Author : Christopher Sackmann; Martin Hallbeck; Emelie Severinsson; Poul Henning Jensen; Linköpings universitet; []
   Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; α-synuclein; amyloid-β; TDP-43; cell to cell transmission;

   Abstract : Neurodegenerative diseases such as Alzheimer’s disease (AD), Parkinson’s disease (PD), frontotemporal lobar dementia (FTLD) and amyotrophic lateral sclerosis (ALS) are disorders characterized by the progressive deposition of proteinaceous inclusions throughout the brain in a predictable manner. Each disease is described by the involvement of different misfolded and aggregated proteins (AD, amyloid-β and tau; PD, α-synuclein; ALS and FTLD, TDP-43) that spread between anatomically connected brain regions, causing cell death in previously healthy regions. READ MORE