Search for dissertations about: "synaptic"

Showing result 1 - 5 of 286 swedish dissertations containing the word synaptic.

  1. 1. Gene therapy for epilepsy: resculpturing synaptic transmission with neuropeptides

    University dissertation from Institutionen för kliniska vetenskaper, Lunds universitet

    Author : Andreas Toft Sörensen; Lund University.; Lunds universitet.; [2008]
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; LTP; synaptic plasticity; synaptic transmission; electrophysiology; Y5 receptor; Y2 receptor; neuropeptide Y NPY ; hippocampus; gene therapy; epilepsy; memory; activity-dependent release; volume transmission;

    Abstract : Intractable seizures and lack of effective antiepileptic drugs (AED) are severe and common conditions affecting many patients with epilepsy. Thus, there is an urgent need to develop new therapies in epilepsy. The search for novel treatments has identified several neuropeptide systems as potential targets for future therapeutic interventions. READ MORE

  2. 2. Role of Endogenous BDNF and NT3 for Synaptic Transmission and Plasticity in the Dentate gyrus

    University dissertation from Section for Restorative Neurology, BMC A11, SE-221 84 Lund, Sweden

    Author : Klara Olofsdotter; Lund University.; Lunds universitet.; [2002]
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; hippocampus; dentate gyrus; GABA; glutamate; synaptic transmission; synaptic plasticity; Brain-derived neurotrophic factor; neurotrophin 3; Neurologi; neurophysiology; neuropsychology; Neurology; electrophysiology; neurofysiologi; neuropsykologi;

    Abstract : The neurotrophins, notably brain-derived neurotrophic factor (BDNF) and neurotrophin 3 (NT3), modulate synaptic transmission and synaptic plasticity in the adult mammalian brain. Recent data suggest that neurotrophins might be mediators of activity-dependent synaptic plasticity. READ MORE

  3. 3. Synaptic transmission and synaptic plasticity in the mouse striatum

    University dissertation from Stockholm : Karolinska Institutet, Department of Physiology and Pharmacology

    Author : Sietske Schotanus; Karolinska Institutet.; Karolinska Institutet.; [2008]
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES;

    Abstract : The striatum is the major input nucleus of the basal ganglia and can be subdivided into a dorsal part and a ventral part that is also named nucleus accumbens (NAc). The dorsal part is involved in motor control and habit learning whereas the ventral part is mostly associated with rewardmotivated behaviors. READ MORE

  4. 4. Immune responses and synaptic protein expression in epilepsy

    University dissertation from Lund University: Faculty of Medicine

    Author : Una Avdic; Lund University.; Lunds universitet.; Lund University.; Lunds universitet.; Lund University.; Lunds universitet.; [2018]
    Keywords : epilepsy; non-convulsive status epileptics; synaptic proteins; immune response; microglia; inflammation;

    Abstract : .... READ MORE

  5. 5. Beyond AMPA and NMDA: Slow synaptic mGlu/TRPC currents Implications for dendritic integration

    University dissertation from Stockholm : KTH

    Author : Marcus Petersson; KTH.; [2010]
    Keywords : NATURVETENSKAP; NATURAL SCIENCES; transient receptor potential; TRP; metabotropic glutamate receptor; mGlu1 5; dendritic integration; synaptic activation; temporal summation; low-frequency; entorhinal cortex; mathematical model; computational neuroscience; TECHNOLOGY Information technology Computer science; TEKNIKVETENSKAP Informationsteknik Datavetenskap;

    Abstract : In order to understand how the brain functions, under normal as well as pathological conditions, it is important to study the mechanisms underlying information integration. Depending on the nature of an input arriving at a synapse, different strategies may be used by the neuron to integrate and respond to the input. READ MORE