Advanced search

Found 5 swedish dissertations matching the above criteria.

  2. 1. Immunomodulation during human pregnancy : placental exosomes as vehicles of immune suppression

    Author : Ann-Christin Stenqvist; Lucia Mincheva-Nilsson; Maria Jenmalm; Umeå universitet; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; exosomes; microvesicles; pregnancy; placenta; syncytiotrophoblast; immune privilege; apoptosis; cytotoxicity; T regulatory cells; NKG2D; MICA B; FasL; TRAIL; immunologi; Immunology;

    Abstract : The mammalian pregnancy comprises a challenge to the maternal immune system since the fetus is semi-allogeneic and could thus be rejected. Pregnancy success is associated with the placenta that is not only essential for oxygen supply, nourishment and pregnancy hormones but also plays a role in the protection of the fetus against maternal immunologic attack. READ MORE

  4. 2. Exosomes and the NKG2D receptor-ligand system in pregnancy and cancer : using stress for survival

    Author : Malin Hedlund; Lucia Mincheva-Nilsson; Susanne Gabrielsson; Umeå universitet; []
    Keywords : Exsosomes; NKG2D; MICA; MICB; ULBP; human placenta; trophoblast; syncytiotrophoblast; thermal stress; oxidative stress; leukemia; lymphoma; immunologi; Immunology;

    Abstract : Although not obvious at first sight, several parallels can be drawn between pregnancy andcancer. Many proliferative, invasive and immune tolerance mechanisms that supportnormal pregnancy are also exploited by malignancies to establish a nutrient supply andevade or edit the immune response of the host. READ MORE

  5. 3. Transport of sodium and protons in the human placenta. Mechanisms in normal pregnancy and alterations in intrauterine growth restriction

    Author : Martin Johansson; Göteborgs universitet; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; placenta; Na K ATPase; Na H exchanger; H K ATPase; intrauterine growth restriction; BeWo cells; epithelial transport;

    Abstract : The syncytiotrophoblast cell of the human placenta represents the interface between maternal and fetal blood supplies. This polarized epithelium consists of a maternal facing microvillous membrane (MVM) opposing a fetal facing basal membrane (BM). This unique syncytial cell is responsible for transfer of all nutrients to the developing fetus. READ MORE

  6. 4. Structure and distribution of alpha-1-microglobulin proteins

    Author : Tord Berggård; Institutionen för experimentell medicinsk vetenskap; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Proteins; lysine; chromophore; placenta; immunohistochemistry; albumin; prothrombin; plasma; bikunin; lipocalin; alpha-1-microglobulin; protein HC; enzymology; Proteiner; enzymologi;

    Abstract : This thesis describes studies of the structure and tissue distribution of alpha-1-microglobulin (a1-m), a member of the lipocalin protein superfamily with immunosuppressive properies. It was shown that a1-m appears in human plasma in five major forms. READ MORE

  7. 5. Cytokines and lipids in pregnancy – effects on developmental programming and placental nutrient transfer

    Author : Susanne Lager; Göteborgs universitet; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; adipose tissue; amino acids; cytokines; developmental programming; free fatty acids; insulin resistance; interleukin-6; lipoprotein lipase; nutrient transport; placenta; toll-like receptor 4;

    Abstract : Metabolic disturbances, in particular those associated with nutritional challenges, that take place during development, both in utero and early postnatal life, have long-lasting health consequences on an individual. The most pronounced evidence of these challenges is a deviation in birth weight. READ MORE