Search for dissertations about: "syndecan."
Showing result 1 - 5 of 26 swedish dissertations containing the word syndecan..
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1. Syndecan-1 insights in mesothelioma
Abstract : Syndecan-1 is a cell surface heparan sulfate proteoglycan expressing on epithelial cells. Heparan sulfate (HS) chains on syndecan-1 constitute growth factor attachment sites and facilitate growth factors to bind their respective receptors. This binding property of HS chains allows syndecan-1 to be involved in various cellular processes. READ MORE
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2. Circulating proteoglycans and glycosaminoglycans during critical illness
Abstract : The endothelial glycocalyx is the carbohydrate rich inner layer of the blood vessels. Important components of the glycocalyx are the proteoglycans with their attached glycosaminoglycans. READ MORE
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3. Role of Heparan Sulfate N-sulfation in Mouse Embryonic Development
Abstract : Heparan sulfate (HS) is a sulfated glycosaminoglycan expressed by all cells in the body. It is found at the cell surface and in the extracellular matrix where it binds a large amount of various ligands including growth factors and morphogens. READ MORE
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4. Endocytosis of therapeutic macromolecules in tumor cells - Mechanistic aspects of the proteoglycan receptor function
Abstract : Novel therapeutics to combat cancer are urgently needed. Most current pharmacological therapies have severe side effects and are seldom curative. Macromolecular drugs, and in particular nucleic acid based drugs, offer a potential remedy for this situation. READ MORE
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5. Studies on syndecan-1 in mesenchymal tumors
Abstract : The syndecans are a four-member family of type I transmembrane proteoglycans. Their core proteins have a short cytoplasmic domain, a transmembrane domain and a large N-terminal extracellular domain possessing glycosaminoglycan chains. All the protein domains and the glycosaminoglycan chains can contribute to the functions of syndecans. READ MORE