Search for dissertations about: "synonymous substitutions"

Showing result 6 - 10 of 10 swedish dissertations containing the words synonymous substitutions.

  2. 6. HIV-1 variability in relation to host defence mechanisms and disease outcome

    Author : Marianne Jansson; Karolinska Institutet; Karolinska Institutet; []
    Keywords : HIV-1; peptides; seroreactivity; genetic variability; pediatric; disease outcome; biological phenotypes; B-chemokines; coreceptors; V3; V2.;

    Abstract : Genetic variability is a major characteristic of HIV-1. Virus variants evolve rapidly, not only globally, but also within single individuals as a result of an error-prone reverse transcriptase, a rapid virus population turnover and selective pressure from the host. READ MORE

  4. 7. The Effects of Mutation and Selection on the Rate and Pattern of Molecular Evolution in Birds

    Author : Sofia Berlin; Hans Ellegren; Adam Eyre-Walker; Uppsala universitet; []
    Keywords : NATURVETENSKAP; NATURAL SCIENCES; Molecular genetics; substitution rate; diversity; selection; male mutation bias; birds; Genetik; Genetics; Genetik;

    Abstract : By comparing sequence diversity and divergence on sex chromosomes one can study how the rate of evolution in affected by mutation and/or selection. The rate of mutation in male biased, meaning that relatively more mutations are created in the male germ line than in the female. READ MORE

  5. 8. Engineering membrane proteins for production and topology

    Author : Stephen Toddo; Daniel Daley; Roslyn Bill; Stockholms universitet; []
    Keywords : NATURVETENSKAP; NATURAL SCIENCES; Membrane protein; Over-expression; Protein production; Codon optimization; Escherichia coli; AraH; NarK; mRNA secondary structure; coding sequence; ribosome binding site; RBS; topology; split-GFP; Biochemistry; biokemi;

    Abstract : The genomes of diverse organisms are predicted to contain 20 – 30% membrane protein encoding genes and more than half of all therapeutics target membrane proteins. However, only 2% of crystal structures deposited in the protein data bank represent integral membrane proteins. READ MORE

  6. 9. HIV disease progression - Impact of HIV-1 intersubtype recombination and association with HIV-2 evolution

    Author : Angelica Palm; Institutionen för experimentell medicinsk vetenskap; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES;

    Abstract : Human immunodeficiency virus type 1 (HIV-1) and type 2 (HIV-2) are both causative agents of AIDS, with similar pathogenic characteristics. However, the rate of disease progression is highly variable both within and between HIV-1 and HIV 2, but the mechanisms involved in modulating the rate of disease progression remain poorly understood. READ MORE

  7. 10. Genetic and antigenic diversity in Pneumocystis jirovecii

    Author : Jessica Beser; Karolinska Institutet; Karolinska Institutet; []
    Keywords : ;

    Abstract : Pneumocystis jirovecii is a human specific, atypical fungus with a worldwide distribution that causes disease in immunocompromised individuals. The fungus proliferates in the lungs where it binds to epithelial alveolar cells, provoking severe pneumonia, denoted pneumocystis pneumonia (PCP). READ MORE