Search for dissertations about: "synovial sarcoma"

Showing result 6 - 10 of 17 swedish dissertations containing the words synovial sarcoma.

  2. 6. Studies of transforming growth factor alpha in normal and abnormal growth

    Author : Anna-Lotta Hallbeck; Åke Wasteson; Thomas Walz; Annelie Lindström; Carl-Henric Heldin; Linköpings universitet; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; TGF-alpha; HER; EGFR; synovia; synovial sarcoma; RA; synovitis; Medical cell biology; Medicinsk cellbiologi;

    Abstract : Regulation of growth is of fundamental importance for development of the organism and to maintain health. The induction of cell proliferation and matrix production are influenced by several different signaling systems, most importantly by growth factors. READ MORE

  4. 7. Soft Tissue Sarcoma Patterns multiplicity, heterogeneity and growth characteristics

    Author : Josefin Fernebro; Bröstcancer-genetik; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; cancerology; Cytologi; oncology; Soft tissue sarcoma; tumor periphery; Medicine human and vertebrates ; Medicin människa och djur ; Cytology; multiple primary tumors; onkologi; cancer;

    Abstract : Soft tissue sarcomas (STS) represent a group of rare and heterogenous tumors that optimally should be diagnosed and treated within multidisciplinary teams. This thesis has studied various aspects ? pathological, genetical, and clinical ? of STS. READ MORE

  5. 8. Activity and mechanism of action of histone deacetylase inhibitors in synovial sarcoma

    Author : Limin Ma; Karolinska Institutet; Karolinska Institutet; []
    Keywords : ;

    Abstract : Synovial sarcoma is a rare but aggressive paediatric soft tissue sarcoma that is driven by the genomic rearrangement t(X;18)(p11.2;q11.2). The resulting fusion protein, SS18- SSX, exhibits oncogenic properties through protein-protein interactions that alter gene transcriptions and chromatin remodelling. READ MORE

  6. 9. The biological role and clinical impact of SYT-SSX fusion gene and IGF-1R in synovial sarcoma

    Author : Yuntao Xie; Karolinska Institutet; Karolinska Institutet; []
    Keywords : Synovial sarcoma; translocation; SYT-SSX; IGF-1R cyclin D1; cell cycle; proliferation; apoptosis.;

    Abstract : Synovial sarcoma, which is a highly malignant soft tissue tumour occurring mainly in young and middle-aged adults, is characterized by the translocation t(X; 18)(p 11.2; q 11.2). READ MORE

  7. 10. Sarcoma ecosystems : spatial characterization and prognostic significance

    Author : Yanhong Su; Karolinska Institutet; Karolinska Institutet; []
    Keywords : ;

    Abstract : Sarcoma is a highly heterogeneous disease with complex biological activities and unique tumor microenvironments (TME) in distinct subtypes. The limited treatment options and inadequate responses to current therapies necessitate a deeper understanding of sarcoma biology and personalized treatment strategies. READ MORE