Search for dissertations about: "synovial"

Showing result 16 - 20 of 159 swedish dissertations containing the word synovial.

  2. 16. Activity and mechanism of action of histone deacetylase inhibitors in synovial sarcoma

    Author : Limin Ma; Karolinska Institutet; Karolinska Institutet; []
    Keywords : ;

    Abstract : Synovial sarcoma is a rare but aggressive paediatric soft tissue sarcoma that is driven by the genomic rearrangement t(X;18)(p11.2;q11.2). The resulting fusion protein, SS18- SSX, exhibits oncogenic properties through protein-protein interactions that alter gene transcriptions and chromatin remodelling. READ MORE

  4. 17. The biological role and clinical impact of SYT-SSX fusion gene and IGF-1R in synovial sarcoma

    Author : Yuntao Xie; Karolinska Institutet; Karolinska Institutet; []
    Keywords : Synovial sarcoma; translocation; SYT-SSX; IGF-1R cyclin D1; cell cycle; proliferation; apoptosis.;

    Abstract : Synovial sarcoma, which is a highly malignant soft tissue tumour occurring mainly in young and middle-aged adults, is characterized by the translocation t(X; 18)(p 11.2; q 11.2). READ MORE

  5. 18. Studies on the therapeutic modulation of inflammation in the synovial membrane of rheumatoid arthritis

    Author : Petra Neregård; Karolinska Institutet; Karolinska Institutet; []
    Keywords : ;

    Abstract : Rheumatoid arthritis (RA) is a chronic autoimmune disease characterized by inflammation of the synovial membrane that can lead to joint deformity and physical disability. Despite recent progress in the therapeutic field of RA, the exact molecular mechanisms responsible for chronic joint inflammation are not yet completely understood. READ MORE

  6. 19. Pain and radiographic changes of the arthritic temporomandibular joint : relation to cytokines in synovial fluid and plasma

    Author : Silvi Nordahl; Karolinska Institutet; Karolinska Institutet; []
    Keywords : Arthritis; Bone loss; Interleukin- 1 beta; Pain; Plasma; Progression; Radiographic changes; Synovial fluid; Temporomandibular joint; Tumor Necrosis Factor alpha;

    Abstract : In patients with rheumatoid arthritis and other inflammatory joint diseases, radiographic changes of the TMJ are frequently observed. Common symptoms of TMJ involvement are pain at rest and on movement of the jaw. READ MORE

  7. 20. Synovial metabolism after different degrees of trauma : effects of pharmacological and physiological intervention : a microdialysis study of the knee joint synovium

    Author : Anders Stålman; Karolinska Institutet; Karolinska Institutet; []
    Keywords : ;

    Abstract : Background: Knee arthroscopy is one of the most common orthopedic procedures. Postoperative pain and knee swelling is often a problem. Optimal pain management in knee arthroscopic procedures is important to permit same-day discharge and to contribute to early mobilisation, reduced cost and increased patient satisfaction. READ MORE