Search for dissertations about: "syntaxin-1"

Showing result 1 - 5 of 9 swedish dissertations containing the word syntaxin-1.

  2. 1. Exocytosis in insulin secreting cells - role of SNARE-proteins

    Author : Jenny Vikman; Diabetes - öcellsexocytos; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; calcium channel; cAMP; syntaxin 1; SNAP-25; SNARE; exocytosis; Insulin secretion; pancreatic beta-cells;

    Abstract : Type 2 diabetes is marked by deterioration in pancreatic β-cell function. SNARE-proteins are crucial for the fusion of insulin granules with the plasma membrane, a prerequisite for insulin secretion. READ MORE

  4. 2. Architecture and function of the insulin granule secretion machinery

    Author : Peng Yin; Sebastian Barg; Herbert Gaisano; Uppsala universitet; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Docking; Syntaxin-1A; Voltage-gated Ca2 Channels; Exocytosis; Type-2 Diabetes;

    Abstract : Insulin is released into the blood stream to normalize elevated blood glucose, for example after a meal. The hormone is synthesized by β-cells in the endocrine pancreas, and stored in small vesicles, known as secretory granules, until required. When glucose is elevated, these granules undergo regulated exocytosis and thereby secrete the hormone. READ MORE

  5. 3. Molecular mechanisms regulating exocytosis : studies of insulin secretion and neurotransmitter release

    Author : Lena Lilja; Karolinska Institutet; Karolinska Institutet; []
    Keywords : Cdk5; cell line; DARPP-32; dephosphorylation; exocytosis; inhibitor-1; insulin; islet; kinase; munc18; myotube; p35; p39; phosphatase; phosphorylation; PP1; presynaptic mechanisms; secretion; subcellular localization.;

    Abstract : In order to achieve normal physiology the secretion of hormones and neurotransmitters needs to be firmly controlled. The basic molecular machinery mediating regulated exocytosis of hormones and neurotransmitters is in principal revealed, but knowledge about how the individual components are spatially and temporarily coordinated is limited. READ MORE

  6. 4. Calcium dynamics and vesicle-release proteins in a prion-infected neuronal cell line

    Author : Malin Sandberg; Karolinska Institutet; Karolinska Institutet; []
    Keywords : Prion; Scrapie; Voltage-gated N-type calcium channels; SNARE proteins; Exocytosis; Long-term depolarization;

    Abstract : The prion particle, PrPSc, is an infectious, misfolded form of the cellular prion protein, PrPC that is expressed at high levels in the central nervous system. Prions cause neurodegenerative diseases with clinical signs including dementia, ataxia and myoclonus. These diseases cause characteristic electroencephalographic changes. READ MORE

  7. 5. Pathophysiological effects of alpha-synuclein on SNARE complex proteins in models of alpha-synucleinopathies

    Author : Emma Brolin; Joakim Bergström; Anna Erlandsson; Martin Ingelsson; Arianna Bellucci; Uppsala universitet; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Alpha-synuclein; Parkinson’s disease; synaptosome; SNARE complex; proximity ligation assay; extracellular vesicles;

    Abstract : Accumulation and spread of alpha-synuclein (α-syn) aggregates are central to the disease pathogenesis of Parkinson’s disease and dementia with Lewy bodies, collectively known as α-synucleinopathies. Native α-syn is a monomeric presynaptic protein that can act as a molecular chaperone for the soluble N-ethylmaleimide-sensitive factor attachment protein receptor (SNARE) complex assembly. READ MORE