Search for dissertations about: "synthesis of antibacterial agents"

Showing result 1 - 5 of 15 swedish dissertations containing the words synthesis of antibacterial agents.

  2. 1. Design and synthesis of KDO-derivatives as inhibitors of lipopolysaccharide biosynthesis in Gram-negative bacteria : a new class of antibacterial agents

    Author : Anita M. Jansson; Stockholms universitet; []
    Keywords : ;

    Abstract : .... READ MORE

  4. 2. Pilicides and Curlicides : Design, synthesis, and evaluation of novel antibacterial agents targeting bacterial virulence

    Author : Erik Chorell; Fredrik Almqvist; Stephen Hanessian; Umeå universitet; []
    Keywords : NATURVETENSKAP; NATURAL SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; pilicide; curlicide; anti-virulence; chaperone usher pathway; antibacterial; pili; curli; Escherichia coli; biofilm inhibitor; 2-pyridone; peptidomimetic; Organic chemistry; Organisk kemi; Bioorganic chemistry; Bioorganisk kemi; Pharmaceutical chemistry; Läkemedelskemi; Organic synthesis; Organisk syntes; Infectious diseases; Infektionssjukdomar; Biorganic Chemistry; bioorganisk kemi; Infectious Diseases; infektionssjukdomar; datorlingvistik; computational linguistics; organisk kemi; Organic Chemistry;

    Abstract : New strategies are needed to counter the growing problem of bacterial resistance to antibiotics. One such strategy is to design compounds that target bacterial virulence, which could work separately or in concert with conventional bacteriostatic or bactericidal antibiotics. READ MORE

  5. 3. Design, synthesis and evaluation of bacterial sialic acid uptake inhibitors

    Author : Tiago Bozzola; Centrum för analys och syntes; []
    Keywords : NATURVETENSKAP; NATURAL SCIENCES; Sialic Acid; antibacterial agents; Medicinal Chemistry; Synthesis; uptake inhibitors;

    Abstract : Antibiotic resistance is a major threat for our society and finding novel antibacterial therapies is of greatimportance. In this thesis, we investigate bacterial sialic acid uptake inhibitors as a novel antibacterial approach.Bacteria do not biosynthesise sialic acid and therefore harvest it from the host. READ MORE

  6. 4. Synthesis of substituted Ring-Fused 2-Pyridones and applications in chemical biology

    Author : Christoffer Bengtsson; Fredrik Almqvist; Paul Helquist; Umeå universitet; []
    Keywords : Synthesis; 2-pyridone; 2-thiazoline; cross coupling; pili; curli; antibacterial; organisk kemi; Organic Chemistry;

    Abstract : Antibiotics have been extensively used to treat bacterial infections since Alexander Fleming’s discovery of penicillin 1928. Disease causing microbes that have become resistant to antibiotic drug therapy are an increasing public health problem. READ MORE

  7. 5. Synthesis and functionalization of ring-fused 2-pyridones : Targeting pili formation in E. coli

    Author : Nils Pemberton; Fredrik Almqvist; Oliver Kappe; Umeå universitet; []
    Keywords : NATURVETENSKAP; NATURAL SCIENCES; 2-pyridone; acylketene; antibacterial; biofilm inhibitor; Mannich; Micro-wave-assisted chemistry; peptidomimetic; virulence.; Organic synthesis; Organisk syntes;

    Abstract : Bicyclic dihydrothiazolo fused 2-pyridones have been studied as a new class of antibacterial agents, termed pilicides, that target the formation of adhesive bacterial surface organelles (pili) in pathogenic bacteria. Synthetic methods to further functionalize the bicyclic 2-pyridone scaffold have been developed in order to increase water-solubility and thereby facilitate biological evalua-tions. READ MORE